Show simple item record

dc.contributor.authorAranaz, Paula
dc.contributor.authorPeña, Adriana
dc.contributor.authorVettorazzi, Ariane
dc.contributor.authorFabra, María José
dc.contributor.authorMartínez-Abad, Antonio
dc.contributor.authorLópez-Rubio, Amparo
dc.contributor.authorPera, Joan
dc.contributor.authorParladé, Javier
dc.contributor.authorCastellari, Massimo
dc.contributor.authorMilagro, Fermín I.
dc.contributor.authorGonzález-Navarro, Carlos J.
dc.contributor.otherIndústries Alimentàriesca
dc.contributor.otherProducció Vegetalca
dc.date.accessioned2022-01-26T12:55:04Z
dc.date.available2022-01-26T12:55:04Z
dc.date.issued2021-11-07
dc.identifier.citationAranaz, Paula, Adriana Peña, Ariane Vettorazzi, María José Fabra, Antonio Martínez-Abad, Amparo López-Rubio, and Joan Pera et al. 2021. "Grifola Frondosa (Maitake) Extract Reduces Fat Accumulation And Improves Health Span In C. Elegans Through The DAF-16/FOXO And SKN-1/NRF2 Signalling Pathways". Nutrients 13 (11): 3968. doi:10.3390/nu13113968.ca
dc.identifier.issn2072-6643ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1566
dc.description.abstractIn recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status. Among them, fungi have gained popularity for their high polysaccharide content and other bioactive components with beneficial activities. Here, we use the C. elegans model to investigate the potential activities of a Grifola frondosa extract (GE), together with the underlying mechanisms of action. Our study revealed that GE represents an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. Treatment with our GE extract, which was found to be nongenotoxic through a SOS/umu test, significantly reduced the fat content of C. elegans, decreased the production of intracellular ROS and aging–lipofuscin pigment, and increased the lifespan of nematodes. Gene expression and mutant analyses demonstrated that the in vivo anti-obesity and antioxidant activities of GE were mediated through the daf-2/daf-16 and skn-1/nrf-2 signalling pathways, respectively. Taken together, our results suggest that our GE extract could be considered a potential functional ingredient for the prevention of obesity-related disturbances.ca
dc.format.extent20ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofNutrientsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGrifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathwaysca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDCDTI/IDI-20170863/ES/Obtención de Componentes bioactivos para el sector agroalimentario mediante procesos de bioconversión y biorrefinería de subproductes de origen animal y vegetal. (2/8)/BIOPROca
dc.subject.udc663/664ca
dc.identifier.doihttps://doi.org/10.3390/nu13113968ca
dc.contributor.groupProtecció Vegetal Sostenibleca
dc.contributor.groupFuncionalitat i Seguretat Alimentàriaca


Files in this item

 
 

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
Share on TwitterShare on LinkedinShare on FacebookShare on TelegramShare on WhatsappPrint