RNA-seq based detection of differentially expressed genes in the skeletal muscle of Duroc pigs with distinct lipid profiles
Ver/Abrir
Autor/a
Cardoso, T. F.
Cánovas, A.
Canela-Xandri, O.
González-Prendes, R.
Amills, M.
Quintanilla, R.
Fecha de publicación
2017-02-14ISSN
2045-2322
Resumen
We have used a RNA-seq approach to investigate differential expression in the skeletal muscle of swine
(N=52) with divergent lipid profiles i.e. HIGH (increased intramuscular fat and muscle saturated and
monounsaturated fatty acid contents, higher serum lipid concentrations and fatness) and LOW pigs
(leaner and with an increased muscle polyunsaturated fatty acid content). The number of mRNAs and
non-coding RNAs (ncRNAs) expressed in the porcine gluteus medius muscle were 18,104 and 1,558,
respectively. At the nominal level of significance (P-value≤0.05), we detected 1,430 mRNA and 12
non-coding RNA (ncRNA) transcripts as differentially expressed (DE) in the gluteus medius muscle of
HIGH vs LOW pigs. This smaller contribution of ncRNAs to differential expression may have biological
and technical reasons. We performed a second analysis, that was more stringent (P-value≤0.01 and fold-change≥ 1.5), and only 96 and 0 mRNA-and ncRNA-encoding genes happened to be DE, respectively. The subset of DE mRNA genes was enriched in pathways related with lipid (lipogenesis and
triacylglycerol degradation) and glucose metabolism. Moreover, HIGH pigs showed a more lipogenic
profile than their LOW counterparts.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
663/664 - Alimentos y nutrición. Enología. Aceites. Grasas
Páginas
9
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Cardoso, T. F., A. Cánovas, O. Canela-Xandri, R. González-Prendes, M. Amills, and R. Quintanilla. 2017. "RNA-Seq Based Detection Of Differentially Expressed Genes In The Skeletal Muscle Of Duroc Pigs With Distinct Lipid Profiles". Scientific Reports 7 (1). doi:10.1038/srep40005.
Número del acuerdo de la subvención
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/AGL2013-48742-C2-1-R/ES/FISIOLOGIA GENOMICA DEL DEPOSITO DE GRASA INTRAMUSCULAR EN PORCINO/
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/AGL2013-48742-C2-2-R/ES/FISIOLOGIA GENOMICA DEL DEPOSITO DE GRASA INTRAMUSCULAR EN PORCINO/
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /
Program
Genètica i Millora Animal
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