Efficacy Studies of a Trivalent Vaccine Containing PCV-2a, PCV-2b Genotypes and Mycoplasma hyopneumoniae When Administered at 3 Days of Age and 3 Weeks Later against Porcine Circovirus 2 (PCV-2) Infection
Mancera-Gracia, José Carlos
Taylor, Lucas P.
Four studies under preclinical and clinical conditions were performed to evaluate the efficacy of a new trivalent vaccine against Porcine circovirus 2 (PCV-2) infection. The product contained inactivated PCV-1/PCV-2a (cPCV-2a) and PCV-1/PCV-2b (cPCV-2b) chimeras, plus M. hyopneumoniae inactivated cell-free antigens, which was administered to piglets in a two-dose regime at 3 days of age and 3 weeks later. The overall results of preclinical and clinical studies show a significant reduction in PCV-2 viraemia and faecal excretion, and lower histopathological lymphoid lesions and PCV-2 immunohistochemistry scores in vaccinated pigs when compared to non-vaccinated ones. Furthermore, in field trial A, a statistically significant reduction in the incidence of PCV-2-subclinical infection, an increase in body weight from 16 weeks of age to slaughterhouse and an average daily weight gain over the whole period (from 3 days of age to slaughterhouse) was detected in the vaccinated group when compared to the non-vaccinated one. Circulation of PCV-2a in field trial A, and PCV-2b plus PCV-2d in field trial B was confirmed by virus sequencing. In conclusion, a double immunization with a cPCV-2a/cPCV-2b/M. hyopneumoniae vaccine was efficacious against PCV-2 infection by reducing the number of histopathological lymphoid lesions and PCV-2 detection in tissues, serum, and faeces, as well as reducing losses in productive parameters.
619 - Veterinary science
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Pleguezuelos, Patricia, Marina Sibila, Raúl Cuadrado-Matías, Rosa López-Jiménez, Diego Pérez, Eva Huerta, Mónica Pérez, Florencia Correa-Fiz, José Carlos Mancera-Gracia, Lucas P. Taylor, Stasia Borowski, Gillian Saunders, Joaquim Segalés, Sergio López-Soria and Mònica Balasch. 2022. "Efficacy Studies Of A Trivalent Vaccine Containing PCV-2A, PCV-2B Genotypes And Mycoplasma Hyopneumoniae When Administered At 3 Days Of Age And 3 Weeks Later Against Porcine Circovirus 2 (PCV-2) Infection". Vaccines 10 (8): 1234. doi:10.3390/vaccines10081234.
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