Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
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Author
Rodon, Jordi
Mykytyn, Anna Z.
Cantero, Guillermo
Albulescu, Irina C.
Bosch, Berend-Jan
Brix, Alexander
Audonnet, Jean-Christophe
Vergara-Alert, Júlia
Haagmans, Bart L.
Publication date
2022-06-24ISSN
2524-4655
Abstract
Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
5
Publisher
BMC
Is part of
One Health Outlook
Citation
Rodon, Jordi, Anna Z. Mykytyn, Guillermo Cantero, Irina C. Albulescu, Berend-Jan Bosch, Alexander Brix, and Jean-Christophe Audonnet et al. 2022. "Protective Efficacy Of An RBD-Based Middle East Respiratory Syndrome Coronavirus (MERS-Cov) Particle Vaccine In Llamas". One Health Outlook 4 (1). doi:10.1186/s42522-022-00068-9.
Grant agreement number
EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI
EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation /VetBioNet
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2811]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/