dc.contributor.author | Rodon, Jordi | |
dc.contributor.author | Mykytyn, Anna Z. | |
dc.contributor.author | Cantero, Guillermo | |
dc.contributor.author | Albulescu, Irina C. | |
dc.contributor.author | Bosch, Berend-Jan | |
dc.contributor.author | Brix, Alexander | |
dc.contributor.author | Audonnet, Jean-Christophe | |
dc.contributor.author | Bensaid, Albert | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Haagmans, Bart L. | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-09-27T08:26:05Z | |
dc.date.available | 2022-09-27T08:26:05Z | |
dc.date.issued | 2022-06-24 | |
dc.identifier.citation | Rodon, Jordi, Anna Z. Mykytyn, Guillermo Cantero, Irina C. Albulescu, Berend-Jan Bosch, Alexander Brix, and Jean-Christophe Audonnet et al. 2022. "Protective Efficacy Of An RBD-Based Middle East Respiratory Syndrome Coronavirus (MERS-Cov) Particle Vaccine In Llamas". One Health Outlook 4 (1). doi:10.1186/s42522-022-00068-9. | ca |
dc.identifier.issn | 2524-4655 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1922 | |
dc.description.abstract | Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV. | ca |
dc.format.extent | 5 | ca |
dc.language.iso | eng | ca |
dc.publisher | BMC | ca |
dc.relation.ispartof | One Health Outlook | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI | ca |
dc.relation.projectID | EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation /VetBioNet | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1186/s42522-022-00068-9 | ca |
dc.contributor.group | Sanitat Animal | ca |