Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats
Blay, M. Teresa
Background. It has been previously shown that acutely administered insect A. diaperinus protein increases food intake in rats and modifies the ex vivo enterohormone secretory profile differently than beef or almond proteins. In this study, we aimed to evaluate whether these effects could be maintained for a longer period and determine the underlying mechanisms. Results. We administered two different insect species to rats for 26 days and measured food intake at different time points. Both insect species increased food intake in the first week, but the effect was later lost. GLP-1 and ghrelin were measured in plasma and ex vivo, and no chronic effects on their secretion or desensitization were found. Nevertheless, digested A. diaperinus acutely modified GLP-1 and ghrelin secretion ex vivo. Conclusion. Our results suggest that increases in food intake could be explained by a local ghrelin reduction acting in the small intestine.
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Is part of
Journal of the Science of Food and Agriculture
Miguéns-Gómez, Alba, Marta Sierra-Cruz, Helena Segú, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Ximena Terra, M. Teresa Blay, Anna Maria Pérez-Vendrell, Montserrat Pinent, and Anna Ardévol. 2022. “Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats”. Journal of the Science of Food and Agriculture. Wiley. doi:10.1002/jsfa.12305.
Grant agreement number
MICIU-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-83477-R/ES/EFECTOS PREVENTIVOS A LARGO PLAZO DE COMPONENTES BIOACTIVOS DE LOS ALIMENTOS EN EL TRACTO GASTROINTESTINAL FRENTE A RETOS METABOLICOS SOBRE LA HOMEOSTASIS: DIETA OBESOGENICA Y/
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS 
Copyright © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/