Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats
Visualitza/Obre
Autor/a
Miguéns-Gómez, Alba
Sierra-Cruz, Marta
Segú, Helena
Beltrán-Debón, Raúl
Rodríguez-Gallego, Esther
Terra, Ximena
Blay, M. Teresa
Pinent, Montserrat
Ardévol, Anna
Data de publicació
2022-11-02ISSN
0022-5142
Resum
Background. It has been previously shown that acutely administered insect A. diaperinus protein increases food intake in rats and modifies the ex vivo enterohormone secretory profile differently than beef or almond proteins. In this study, we aimed to evaluate whether these effects could be maintained for a longer period and determine the underlying mechanisms. Results. We administered two different insect species to rats for 26 days and measured food intake at different time points. Both insect species increased food intake in the first week, but the effect was later lost. GLP-1 and ghrelin were measured in plasma and ex vivo, and no chronic effects on their secretion or desensitization were found. Nevertheless, digested A. diaperinus acutely modified GLP-1 and ghrelin secretion ex vivo. Conclusion. Our results suggest that increases in food intake could be explained by a local ghrelin reduction acting in the small intestine.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Pàgines
8
Publicat per
Wiley
Publicat a
Journal of the Science of Food and Agriculture
Citació
Miguéns-Gómez, Alba, Marta Sierra-Cruz, Helena Segú, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Ximena Terra, M. Teresa Blay, Anna Maria Pérez-Vendrell, Montserrat Pinent, and Anna Ardévol. 2022. “Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats”. Journal of the Science of Food and Agriculture. Wiley. doi:10.1002/jsfa.12305.
Número de l'acord de la subvenció
MICIU-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-83477-R/ES/EFECTOS PREVENTIVOS A LARGO PLAZO DE COMPONENTES BIOACTIVOS DE LOS ALIMENTOS EN EL TRACTO GASTROINTESTINAL FRENTE A RETOS METABOLICOS SOBRE LA HOMEOSTASIS: DIETA OBESOGENICA Y/
Programa
Nutrició Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
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Drets
Copyright © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry
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