Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs
Visualitza/Obre
Autor/a
Viñes, Joaquim
Fàbregas, Norma
Pérez, Daniel
Cuscó, Anna
Fonticoba, Rocío
Francino, Olga
Ferrer, Lluís
Andón Mañero, Miquel
Data de publicació
2022-11-15ISSN
2079-6382
Resum
Staphylococcus pseudintermedius, a common commensal canine bacterium, is the main cause
of skin infections in dogs and is a potential zoonotic pathogen. The emergence of methicillin-resistant
S. pseudintermedius (MRSP) has compromised the treatment of infections caused by these bacteria.
In this study, we compared the phenotypic results obtained by minimum inhibitory concentration
(MICs) for 67 S. pseudintermedius isolates from the skin of nine healthy dogs versus the genotypic data
obtained with Nanopore sequencing. A total of 17 antibiotic resistance genes (ARGs) were detected
among the isolates. A good correlation between phenotype and genotype was observed for some
antimicrobial classes, such as ciprofloxacin (fluoroquinolone), macrolides, or tetracycline. However,
for oxacillin (beta-lactam) or aminoglycosides the correlation was low. Two antibiotic resistance
genes were located on plasmids integrated in the chromosome, and a third one was in a circular
plasmid. To our knowledge, this is the first study assessing the correlation between phenotype and
genotype regarding antimicrobial resistance of S. pseudintermedius from healthy dogs using Nanopore
sequencing technology.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
15
Publicat per
MDPI
Publicat a
Antibiotics
Citació
Viñes, Joaquim, Norma Fàbregas, Daniel Pérez, Anna Cuscó, Rocío Fonticoba, Olga Francino, Lluís Ferrer, and Lourdes Migura-Garcia. 2022. "Concordance Between Antimicrobial Resistance Phenotype And Genotype Of Staphylococcus Pseudintermedius From Healthy Dogs". Antibiotics 11 (11): 1625. doi:10.3390/antibiotics11111625.
Número de l'acord de la subvenció
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTI2018-101991-B-I00/ES/From whole genome sequencing to clinical metagenomics: investigations on the pathogenesis of staphylococcus pseudintermedius pyoderma in the dog/
Programa
Sanitat Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
- ARTICLES CIENTÍFICS [2811]
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/