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Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
dc.contributor.author | Te, Nigeer | |
dc.contributor.author | Rodon Aldrufeu, Jordi | |
dc.contributor.author | Creve, Rhea | |
dc.contributor.author | Pérez, Mónica | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Bensaid, Albert | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2023-02-13T13:14:19Z | |
dc.date.available | 2023-02-13T13:14:19Z | |
dc.date.issued | 2022-09-02 | |
dc.identifier.citation | Te, Nigeer, Jordi Rodon, Rhea Creve, Mónica Pérez, Joaquim Segalés, Júlia Vergara-Alert, and Albert Bensaid. 2022. "Evaluation Of Alpaca Tracheal Explants As An Ex Vivo Model For The Study Of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) Infection". Veterinary Research 53 (1). doi:10.1186/s13567-022-01084-3. | ca |
dc.identifier.issn | 0928-4249 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2072 | |
dc.description.abstract | Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to public health. Here, we established an ex vivo alpaca tracheal explant (ATE) model using an air-liquid interface culture system to gain insights into MERS-CoV infection in the camelid lower respiratory tract. ATE can be infected by MERS-CoV, being 103 TCID50/mL the minimum viral dosage required to establish a productive infection. IFNs and antiviral ISGs were not induced in ATE cultures in response to MERS-CoV infection, strongly suggesting that ISGs expression observed in vivo is rather a consequence of the IFN induction occurring in the nasal mucosa of camelids. | ca |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | BMC | ca |
dc.relation.ispartof | Veterinary Research | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation /VetBioNet | ca |
dc.relation.projectID | EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1186/s13567-022-01084-3 | ca |
dc.contributor.group | Sanitat Animal | ca |
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