A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting
Visualitza/Obre
Autor/a
Chrun, Tiphany
Lacôte, Sandra
Urien, Céline
Jouneau, Luc
Barc, Céline
Bouguyon, Edwige
Contreras, Vanessa
Ferrier-Rembert, Audrey
Peyrefitte, Christophe N.
Busquets, Nuria
Marianneau, Philippe
Schwartz-Cornil, Isabelle
Data de publicació
2018-04-20ISSN
2059-0105
Resum
Rift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent vectors are present, vaccine development is an urgent priority as no licensed vaccines are available outside areas of endemicity. In this study, we evaluated in sheep the protective immunity induced by DNA vaccines encoding the extracellular portion of the Gn antigen which was either or not targeted to antigen-presenting cells. The DNA encoding untargeted antigen was the most potent at inducing IgG responses, although not neutralizing, and conferred a significant clinical and virological protection upon infectious challenge, superior to DNA vaccines encoding the targeted antigen. A statistical analysis of the challenge parameters supported that the anti-eGn IgG, rather than the T-cell response, was instrumental in protection. Altogether, this work shows that a DNA vaccine encoding the extracellular portion of the Gn antigen confers substantial—although incomplete—protective immunity in sheep, a natural host with high preclinical relevance, and provides some insights into key immune correlates useful for further vaccine improvements against the Rift Valley fever virus.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Pàgines
13
Publicat per
Nature Research
Publicat a
npj Vaccines
Citació
Chrun, Tiphany, Sandra Lacôte, Céline Urien, Luc Jouneau, Céline Barc, Edwige Bouguyon, and Vanessa Contreras et al. 2018. "A Rift Valley Fever Virus Gn Ectodomain-Based DNA Vaccine Induces A Partial Protection Not Improved By APC Targeting". Npj Vaccines 3 (1). Springer Nature. doi:10.1038/s41541-018-0052-x.
Programa
Sanitat Animal
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