Using genome wide association studies to identify common QTL regions in three different genetic backgrounds based on Iberian pig breed
Visualitza/Obre
Autor/a
Martínez-Montes, Ángel M.
Fernández, Almudena
Muñoz, María
Noguera, Jose Luis
Folch, Josep M.
Fernández, Ana I.
Data de publicació
2018-03-09ISSN
1932-6203
Resum
One of the major limitation for the application of QTL results in pig breeding and QTN identification has been the limited number of QTL effects validated in different animal material. The aim
of the current work was to validate QTL regions through joint and specific genome wide association and haplotype analyses for growth, fatness and premier cut weights in three different genetic backgrounds, backcrosses based on Iberian pigs, which has a major role in the analysis
due to its high productive relevance. The results revealed nine common QTL regions, three segregating in all three backcrosses on SSC1, 0–3 Mb, for body weight, on SSC2, 3–9 Mb, for loin
bone-in weight, and on SSC7, 3 Mb, for shoulder weight, and six segregating in two of the three
backcrosses, on SSC2, SSC4, SSC6 and SSC10 for backfat thickness, shoulder and ham
weights. Besides, 18 QTL regions were specifically identified in one of the three backcrosses,
five identified only in BC_LD, seven in BC_DU and six in BC_PI. Beyond identifying and validating QTL, candidate genes and gene variants within the most interesting regions have been
explored using functional annotation, gene expression data and SNP identification from RNASeq data. The results allowed us to propose a promising list of candidate mutations, those identified in PDE10A, DHCR7, MFN2 and CCNY genes located within the common QTL regions
and those identified near ssc-mir-103-1 considered PANK3 regulators to be further analysed.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Pàgines
21
Publicat per
PLoS ONE
Publicat a
Public Library of Science
Citació
Martínez-Montes, Ángel M., Almudena Fernández, María Muñoz, Jose Luis Noguera, Josep M. Folch, and Ana I. Fernández. 2018. "Using Genome Wide Association Studies To Identify Common QTL Regions In Three Different Genetic Backgrounds Based On Iberian Pig Breed". PLOS ONE 13 (3): e0190184. Public Library of Science (PLoS). doi:10.1371/journal.pone.0190184.
Número de l'acord de la subvenció
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2014-56369-C2-2-R/ES/VALIDACION GENETICA Y FUNCIONAL DE QTLS, GENES Y REDES GENICAS Y ESTUDIO DEL EFECTO DEL MICROBIOMA EN EL CRECIMIENTO, DEPOSICION DE GRASA Y CALIDAD DE LA CARNE EN PORCINO S2/
Programa
Genètica i Millora Animal
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