The Cipher Code of Simple Sequence Repeats in “Vampire Pathogens”
Ver/Abrir
Autor/a
Zou, Geng
Bello-Orti, Bernardo
Tucker, Alexander W.
Luo, Rui
Ren, Pinxing
Bi, Dingren
Zhou, Rui
Jin, Hui
Fecha de publicación
2015-07-28ISSN
2045-2322
Resumen
Blood inside mammals is a forbidden area for the majority of prokaryotic microbes; however, red blood cells tropism microbes, like “vampire pathogens” (VP), succeed in matching scarce nutrients and surviving strong immunity reactions. Here, we found VP of Mycoplasma, Rhizobiales, and Rickettsiales showed significantly higher counts of (AG)n dimeric simple sequence repeats (Di-SSRs) in the genomes, coding and non-coding regions than non Vampire Pathogens (N_VP). Regression analysis indicated a significant correlation between GC content and the span of (AG)n-Di-SSR variation. Gene Ontology (GO) terms with abundance of (AG)3-Di-SSRs shared by the VP strains were associated with purine nucleotide metabolism (FDR< 0.01), indicating an adaptation to the limited availability of purine and nucleotide precursors in blood. Di-amino acids coded by (AG)n-Di-SSRs included all three six-fold code amino acids (Arg, Leu and Ser) and significantly higher counts of Diamino acids coded by (AG)3, (GA)3, and (TC)3 in VP than N_VP. Furthermore, significant differences (P< 0.001) on the numbers of triplexes formed from (AG)n-Di-SSRs between VP and N_VP in Mycoplasma suggested the potential role of (AG)n-Di-SSRs in gene regulation.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
14
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Zou, Geng, Bernardo Bello-Orti, Virginia Aragon, Alexander W. Tucker, Rui Luo, Pinxing Ren, Dingren Bi, Rui Zhou, and Hui Jin. 2015. "The Cipher Code Of Simple Sequence Repeats In “Vampire Pathogens”". Scientific Reports 5 (1). doi:10.1038/srep12441.
Program
Sanitat Animal
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