Efficacy of multivalent recombinant herpesvirus of turkey vaccines against high pathogenicity avian influenza, infectious bursal disease, and Newcastle disease viruses
Visualitza/Obre
Autor/a
Criado, Miria F.
Kassa, Aemro
Kwon, Jung-Hoon
Sá e Silva, Mariana
Killmaster, Lindsay
Ross, Ted M.
Mebatsion, Teshome
Swayne, David E.
Data de publicació
2023-04-01ISSN
0264-410X
Resum
Vaccines are an essential tool for the control of viral infections in domestic animals. We generated recombinant vector herpesvirus of turkeys (vHVT) vaccines expressing computationally optimized broadly reactive antigen (COBRA) H5 of avian influenza virus (AIV) alone (vHVT-AI) or in combination with virus protein 2 (VP2) of infectious bursal disease virus (IBDV) (vHVT-IBD-AI) or fusion (F) protein of Newcastle disease virus (NDV) (vHVT-ND-AI). In vaccinated chickens, all three vHVT vaccines provided 90–100% clinical protection against three divergent clades of high pathogenicity avian influenza viruses (HPAIVs), and significantly decreased number of birds and oral viral shedding titers at 2 days post-challenge compared to shams. Four weeks after vaccination, most vaccinated birds had H5 hemagglutination inhibition antibody titers, which significantly increased post-challenge. The vHVT-IBD-AI and vHVT-ND-AI vaccines provided 100% clinical protection against IBDVs and NDV, respectively. Our findings demonstrate that multivalent HVT vector vaccines were efficacious for simultaneous control of HPAIV and other viral infections.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
619 - Veterinària
Pàgines
12
Publicat per
Elsevier
Publicat a
Vaccine
Citació
Criado, Miria F., Aemro Kassa, Kateri Bertran, Jung-Hoon Kwon, Mariana Sá e Silva, Lindsay Killmaster, Ted M. Ross, Teshome Mebatsion, and David E. Swayne. 2023. "Efficacy Of Multivalent Recombinant Herpesvirus Of Turkey Vaccines Against High Pathogenicity Avian Influenza, Infectious Bursal Disease, And Newcastle Disease Viruses". Vaccine 41 (18): 2893-2904. doi:10.1016/j.vaccine.2023.03.055.
Programa
Sanitat Animal
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