A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems
Ver/Abrir
Autor/a
Daneshian, Mardas
Botana, Luis M.
Bottein, Marie-Yasmine Dechraoui
Buckland, Gemma
Dennison, Ngaire
Dickey, Robert W.
Fessard, Valérie
Hartung, Thomas
Humpage, Andrew
Leist, Marcel
Molgó, Jordi
Quilliam, Michael A.
Rovida, Costanza
Suarez-Isla, Benjamin A.
Tubaro, Aurelia
Wagner, Kristina
Zoller, Otmar
Dietrich, Daniel
Fecha de publicación
2013-11-01ISSN
1868-596X
Resumen
Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin – marine biotoxins – poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse as well as the rat bioassay. Besides ethical concerns, there is also a need for more reliable test methods because of low inter-species comparability, high intra-species variability, the high number of false positive and negative results as well as questionable extrapolation of quantitative risk to humans. For this reason, a transatlantic group of experts in the field of marine biotoxins was convened from academia and regulatory safety authorities to discuss future approaches to marine biotoxin testing. In this report they provide a background on the toxin classes, on their chemical characterization, the epidemiology, on risk assessment and management, as well as on their assumed mode of action. Most importantly, physiological functional assays such as in vitro bioassays and also analytical techniques, e.g., liquid chromatography coupled mass spectrometry (LC-MS), as substitutes for the rodent bioassay are reviewed. This forms the basis for recommendations on methodologies for hazard monitoring and risk assessment, establishment of causality of intoxications in human cases, a roadmap for research and development of human-relevant functional assays, as well as new approaches for a consumer directed safety concept.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
574 - Ecología general y biodiversidad
Páginas
59
Publicado por
ALTEX Edition
Publicado en
ALTEX - Alternatives to Animal Experimentation
Citación
Daneshian, M., L. M. Botana, M.-Y. Dechraoui Bottein, G. Buckland, M. Campàs, N. Dennison, R. W. Dickey, J. Diogène, et al. 2013 “A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems”. ALTEX - Alternatives to animal experimentation 30(4): 487–545. doi: 10.14573/altex.2013.4.487.
Program
Aigües Marines i Continentals
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