Mycobacterium manresensis induces trained immunity in vitro
Autor/a
de Homdedeu, Miquel
Sanchez-Moral, Lidia
Violán, Concepció
Ràfols, Neus
Ouchi, Dan
Martín, Berta
Peinado, Miguel A.
Rodríguez-Cortés, Alhelí
Arch-Sisquella, Marta
Perez-Zsolt, Daniel
Muñoz Basagoiti, Jordana
Izquierdo-Useros, Nuria
Salvador, Betlem
Matllo, Joan
Vilaplana, Cristina
Torán-Monserrat, Pere
Morros, Rosa
Monfà, Ramon
Sarrias, Maria-Rosa
Cardona, Pere-Joan
Fecha de publicación
2023-05-13ISSN
2589-0042
Resumen
The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease. Our objective was to analyze whether heat-killed Mycobacterium manresensis (hkMm), an environmental mycobacterium, induces trained immunity and confers protection against SARS-CoV-2 infection. To this end, THP-1 cells and primary monocytes were trained with hkMm. The increased secretion of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-1β, and IL-10, metabolic activity, and changes in epigenetic marks suggested hkMm-induced trained immunity in vitro. Healthcare workers at risk of SARS-CoV-2 infection were enrolled into the MANRECOVID19 clinical trial (NCT04452773) and were administered Nyaditum resae (NR, containing hkMm) or placebo. No significant differences in monocyte inflammatory responses or the incidence of SARS-CoV-2 infection were found between the groups, although NR modified the profile of circulating immune cell populations. Our results show that M. manresensis induces trained immunity in vitro but not in vivo when orally administered as NR daily for 14 days.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
28
Publicado por
Cell Press
Publicado en
iScience
Citación
de Homdedeu, Miquel, Lidia Sanchez-Moral, Concepció Violán, Neus Ràfols, Dan Ouchi, Berta Martín, Miguel A. Peinado, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi López-Serrano, Joaquim Segalés, Cristina Vilaplana, Pere Torán-Monserrat, Rosa Morros, Ramon Monfà, Maria-Rosa Sarrias, and Pere-Joan Cardona. 2023. "Mycobacterium Manresensis Induces Trained Immunity In Vitro". Iscience 26 (6): 106873. doi:10.1016/j.isci.2023.106873.
Número del acuerdo de la subvención
EU/H2020/847762/EC/A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients/SMA-TB
MICIU/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/FJC2019-041213-I/ES//
MICINN/Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-117145RB-I00/ES/Nuevas terapias antivirales e inmunomoduladoras frente al SARS-COV-2/
EU/H2020/101046118/EC/RBD Dimer recombinant protein vaccine against SARSCoV2/RBDCOV
Program
Sanitat Animal
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