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Advances and gaps in SARS-CoV-2 infection models

dc.contributor.authorMuñoz-Fontela, César
dc.contributor.authorWiderspick, Lina
dc.contributor.authorAlbrecht, Randy A.
dc.contributor.authorBeer, Martin
dc.contributor.authorCarroll, Miles W.
dc.contributor.authorde Wit, Emmie
dc.contributor.authorDiamond, Diamond
dc.contributor.authorDowling, William E.
dc.contributor.authorFunnell, Simon G. P.
dc.contributor.authorGarcía-Sastre, Adolfo
dc.contributor.authorGerhards, Nora M.
dc.contributor.authorde Jong, Rineke
dc.contributor.authorMunster, Vincent J.
dc.contributor.authorNeyts, Johan
dc.contributor.authorPerlman, Stanley
dc.contributor.authorReed, Douglas S.
dc.contributor.authorRicht, Juergen A.
dc.contributor.authorRiveros-Balta, Ximena
dc.contributor.authorRoy, Chad J.
dc.contributor.authorSalguero, Francisco J.
dc.contributor.authorSchotsaert, Michael
dc.contributor.authorSchwartz, Lauren M.
dc.contributor.authorSeder, Robert A.
dc.contributor.authorSegalés, Joaquim
dc.contributor.authorVasan, Seshadri S.
dc.contributor.authorHenao-Restrepo, Ana María
dc.contributor.authorBarouch, Dan H.
dc.contributor.otherProducció Animalca
dc.date.accessioned2024-01-17T11:34:55Z
dc.date.available2024-01-17T11:34:55Z
dc.date.issued2022-01-13
dc.identifier.citationMuñoz-Fontela, César, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie De Wit, Michael S. Diamond, et al. 2022.“Advances and Gaps in SARS-CoV-2 Infection Models.” PLOS Pathogens 18(1): e1010161. doi:10.1371/journal.ppat.1010161.ca
dc.identifier.issn1553-7366ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/2705
dc.description.abstractAU The:global Pleaseco response nfirmthata tollhe Coronavirus adinglevelsa Disease rerepres 2019 entedcor (COVID-19) rectly: is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.ca
dc.description.sponsorshipThe authors received no specific funding for this work.ca
dc.format.extent15ca
dc.language.isoengca
dc.publisherPublic Library of Scienceca
dc.relation.ispartofPLoS Pathogensca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAdvances and gaps in SARS-CoV-2 infection modelsca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1010161ca
dc.contributor.groupSanitat Animalca


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