Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
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Author
Casella, Valentina
Cebollada Rica, Paula
González-Cao, María
Güerri-Fernandez, Roberto
Bocharov, Gennady
Meyerhans, Andreas
Publication date
2024-05-17ISSN
1999-4915
Abstract
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to eliminate virus-infected cells. Since T cell exhaustion is a physiological process to
reduce immunopathology, the reinvigoration of these cells might be associated with an augmentation
of pathological changes. To test this possibility, we here analyzed in the model system of chronic
lymphocytic choriomeningitis virus (LCMV)-infected mice whether treatment with the checkpoint
inhibitor anti-PD-L1 antibody would increase CD8 T cell-dependent fibrosis. We show that preexisting spleen fibrosis did not worsen under conditions that increase CD8 T cell functionality
and reduce virus loads suggesting that the CD8 T cell functionality increase remained below its
pathogenicity threshold. These promising findings should further encourage immunotherapeutic
trials against chronic virus infections.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
9
Publisher
MDPI
Is part of
Viruses
Citation
Casella, Valentina, Paula Cebollada Rica, Jordi Argilaguet, Enric Vidal, María González-Cao, Roberto Güerri-Fernandez, Gennady Bocharov, and Andreas Meyerhans. 2024. “Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control Without Augmenting Tissue Damage by Fibrosis.” Viruses 16 (5): 799. doi:10.3390/v16050799
Grant agreement number
MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/PID2022-141395OB-I00/ES/COORDINACION Y COOPERACION DE CELULAS INMUNES DURANTE INFECCIONES VIRALES AGUDAS Y CRONICAS/
FEDER/ / /EU/ /
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2838]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/