FlagT4G Vaccine Prevents Transplacental Transmission of Highly Virulent Classical Swine Fever Virus after Single Vaccination in Pregnant Sows
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Author
Muñoz-Aguilera, Adriana
Martínez, Patricia
Alberch, Mònica
Gladue, Douglas P.
Borca, Manuel V.
Publication date
2024-07-23ISSN
2076-393X
Abstract
The transplacental transmission of CSFV and the resulting persistent congenital infection in newborn piglets have been abundantly discussed in pregnant sows suffering from virus infection. Importantly, the availability of safe commercial vaccines with proven efficacy to prevent the generation of congenital and postnatal persistent infections in pregnant sows are critical tools for controlling the disease in CSF endemic areas. Here, we demonstrate the high efficacy of a single dose of the recombinant FlagT4G vaccine to provide solid protection in pregnant sows against transplacental transmission of a highly virulent CSFV. Pregnant sows vaccinated with FlagT4G at 44 days of gestation elicited a strong CSFV-specific antibody response, with neutralizing antibody levels above those required for protection against CSFV. Importantly, after the challenge with a highly virulent CSFV, all foetuses from FlagT4G-vaccinated sows lacked CSF macroscopic lesions and showed a complete absence of the challenge virus in their internal organs at day 79 of gestation. Therefore, pregnant sows safely vaccinated with FlagT4G without affecting reproductive efficacy are efficaciously protected, along with their foetuses, against the infection and disease caused by a CSFV virulent field strain.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
14
Publisher
MDPI
Is part of
Vaccines
Citation
Coronado, Liani, Adriana Muñoz-Aguilera, Guillermo Cantero, Patricia Martínez, Mònica Alberch, Rosa Rosell, Douglas P. Gladue, Manuel V. Borca, and Llilianne Ganges. 2024. “FlagT4G Vaccine Prevents Transplacental Transmission of Highly Virulent Classical Swine Fever Virus After Single Vaccination in Pregnant Sows.” Vaccines 12 (8): 832. https://doi.org/10.3390/vaccines12080832.
Grant agreement number
MICINN/Programa Estatal para impulsar la investigación científico-técnica y su transferencia/PID2021-125599OB-I00/ES/FACTORES DEL VIRUS Y DEL HOSPEDADOR COMO DIANAS PARA EL DISEÑO DE UNA NUEVA ESTRATEGIA DIVA FRENTE A LA PESTE PORCINA CLÁSICA/
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2685]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/