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Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters
(MDPI, 2022-11-10)
Background: Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination ...
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
(Public Library of Science, 2022-11-09)
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease ...
Rules of thumb to obtain, isolate, and preserve porcine peripheral blood mononuclear cells
(Elsevier, 2022-07-16)
One of the most used biospecimens in immunology are peripheral blood mononuclear cells (PBMC). PBMC are particularly useful when evaluating immunity through responses of circulating B- and T-cells, ...
Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
(Frontiers Media, 2022-05-04)
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 ...
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
(Cell Press, 2022-01-24)
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
(MDPI, 2022-09-02)
Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G ...
Postbiotic yeast fermentation product supplementation to lactating goats increases the efficiency of milk production by enhancing fiber digestibility and ruminal propionate, and reduces energy losses in methane
(Oxford University Press, 2022-11-07)
Although in vitro data with mixed ruminal fluid demonstrated positive effects of posbiotic diet (POS) from lactobacilli on measures of fermentation and microbial profiles, there is a paucity of in vivo ...
Clinical characteristics and management of neurocysticercosis patients: a retrospective assessment of case reports from Europe
(Oxford University Press, 2022-10-12)
Objectives: Neurocysticercosis (NCC) is a parasitic disease caused by the larval stage of the tapeworm Taenia
solium. NCC mainly occurs in Africa, Latin America and South-East Asia and can cause a ...
Trends in the interest in COVID-19 news of the local media and their readers: The case of Spain
(SAGE Publications, 2022-08-05)
The COVID-19 has caused not just an unprecedented sanitary crisis but a social crisis, which has affected, among many other fields, the local journalism, which had to adapt to meet the public’s information ...
Advances and gaps in SARS-CoV-2 infection models
(Public Library of Science, 2022-01-13)
AU The:global Pleaseco response nfirmthata tollhe Coronavirus adinglevelsa Disease rerepres 2019 entedcor (COVID-19) rectly: is now facing new challenges such as vaccine inequity and the emergence of ...