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Low CD4/CD8 ratio in classical swine fever postnatalpersistent infection generated at 3 weeks after birth
(Wiley, 2018-11-20)
Classical swine fever virus (CSFV) is one of the most important pathogens affectingswine. After infection with a moderate virulence strain at 8 hours after birth, CSFV isable to induce viral persistence. ...
CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD
(BMJ Publishing Group, 2019-05-16)
Objective To investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer’s disease (AD), and associated ...
Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
(MDPI, 2024-05-17)
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to ...
Differences in skin test reactions to official and defined antigens in guinea pigs exposed to non-tuberculous and tuberculous bacteria
(Nature Research, 2023-02-20)
The single and comparative intradermal tuberculin tests (SITT and CITT) are official in vivo tests for bovine tuberculosis (TB) diagnosis using bovine and avian purified protein derivatives (PPD-B and ...
Disease-specific changes in reelin protein and mRNA in neurodegenerative diseases
(MDPI, 2020-05-19)
Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during ...
TREM2 expression in the brain and biological fluids in prion diseases
(Springer, 2021-04-21)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative ...
Adiaspiromycoses in wild rodents from the Pyrenees, north-eastern Spain
(Wildlife Disease Association, 2024-04-05)
Adiaspiromycosis is a non-transmissible infectious pulmonary disease caused by the inhalation
of propagules from fungal species belonging to the family Ajellomicetaceae,
especially Emergomyces crescens. ...
Lack of detection of Mycobacterium microti infection in wild rodents from a free‑ranging wild boar outbreak area
(Springer, 2023-10-18)
Wild small rodents are considered the natural reservoirs of Mycobacterium microti, a member of the Mycobacterium tuberculosis complex (MTBC) that can cause tuberculosis (TB) in humans and animals, as ...
Immunogenicity and protection against Mycobacterium caprae challenge in goats vaccinated with BCG and revaccinated after one year
(MDPI, 2020-12-10)
Vaccination has been proposed as a supplementary tool for the control of tuberculosis in livestock. The long-term immunogenicity elicited by bacillus Calmette-Guerin (BCG) and the efficacy of revaccination ...
Evaluation of P22 antigenic complex for the immuno-diagnosis of Tuberculosis in BCG vaccinated and unvaccinated goats
(Frontiers Media, 2020-07-03)
Current eradication strategies of tuberculosis (TB) in goats mainly rely on the single intradermal tuberculin test (SIT) and single intradermal cervical comparative tuberculin tests (SICCTs). TB vaccination ...