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Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
(Public Library of Science, 2019-10-23)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Mycobacterium microti Infection in free-ranging wild boar, Spain, 2017-2019
(Centers for Disease Control and Prevention, 2019-11-25)
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes pathology in many mammals. M. microti infections have been found in some countries in Europe. We report an outbreak ...
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
(Public Library of Science, 2022-11-09)
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease ...
Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2
(MDPI, 2024-05-09)
African swine fever (ASF) is a deadly disease of swine currently causing a worldwide
pandemic, leading to severe economic consequences for the porcine industry. The control of disease
spread is hampered ...
Evidence of p75 Neurotrophin Receptor Involvement in the Central Nervous System Pathogenesis of Classical Scrapie in Sheep and a Transgenic Mouse Model
(MDPI, 2021-03-08)
Neurotrophins constitute a group of growth factor that exerts important functions in the nervous system of vertebrates. They act through two classes of transmembrane receptors: tyrosine-kinase receptors ...
Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Public Library of Science, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...
Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models
(Nature Research, 2020-03-19)
Phenotypic variability in prion diseases, such as scrapie, is associated to the existence of prion strains, which are different pathogenic prion protein (PrPSc) conformations with distinct pathobiological ...
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
(BMC, 2022-12-13)
Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective ...
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation
(Springer Nature, 2023-12-18)
Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that
contribute to these fates are described, the critical control points and ...