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Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
(MDPI, 2024-05-17)
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to ...
A shift in Porcine circovirus 3 (PCV‐3) history paradigm: Phylodynamic analyses reveal an ancient origin and prolonged undetected circulation in the worldwide swine population
(Wiley Open Access, 2019-09-30)
The identification of a new circovirus (Porcine circovirus 3, PCV-3) has raised a remarkable concern because of some analogies with Porcine circovirus 2 (PCV-2). Preliminary results suggest an extremely ...
Detection of West Nile virus lineage 2 in North‐Eastern Spain (Catalonia)
(Wiley, 2018-12-01)
In September 2017, West Nile virus (WNV) lineage 2 was detected in Catalonia (Northern Spain) in northern goshawks by passive surveillance. The phylogenetic analyses showed that it was related to the ...
Selecting Subpopulations of High-Quality Protein Conformers among Conformational Mixtures of Recombinant Bovine MMP-9 Solubilized from Inclusion Bodies
(MDPI, 2021-03-16)
A detailed workflow to analyze the physicochemical characteristics of mammalian matrix metalloproteinase (MMP-9) protein species obtained from protein aggregates (inclusion bodies—IBs) was followed. ...
Ecological Factors Driving Avian Influenza Virus Dynamics in Spanish Wetland Ecosystems
(Public Library of Science, 2012-11-12)
Studies exploring the ecological interactions between avian influenza viruses (AIV), natural hosts and the environment are
scarce. Most work has focused on viral survival and transmission under laboratory ...
Identification of a Newly Conserved SLA-II Epitope in a Structural Protein of Swine Influenza Virus
(Frontiers Media, 2020-09-16)
Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully ...
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant
(Frontiers Media, 2023-12-04)
Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or
their subunits. However, S shows some structural instability that limits its
immunogenicity and production, hampering the ...
Understanding host-microbiota interactions in the commercial piglet around weaning
(Nature Research, 2021-12-06)
Weaning is a critical period in the life of pigs with repercussions on their health and welfare and on the
economy of the swine industry. This study aimed to assess the efect of the commercial early ...
Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health
(MDPI, 2021-05-08)
Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines ...
One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island
(MDPI, 2023-05-28)
The increase in the reptile population has led to a rise in the number of zoonotic infections due to close contact with reptiles, with reptile-associated salmonellosis being particularly relevant. ...