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Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein
(Elsevier, 2019-09-09)
Middle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one third of human patients. In recent years, several investigators developed protective ...
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection
(Public Library of Science, 2021-05-24)
While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate ...
Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus
(MDPI, 2020-07-17)
This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high ...
Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology
(Elsevier, 2023-09-17)
Camelids are economically and socially important in several parts of the world and might carry pathogens with
epizootic or zoonotic potential. However, biological research in these species is limited ...
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
(Taylor & Francis Open Access, 2022-02-01)
Middle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle East region are subdivided into two clades (A and B), all ...
The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks
(Taylor and Francis, 2023-11-03)
Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry.
However, it is unclear whether feathers play an active role in viral transmission. This ...
Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
(Elsevier, 2024-03)
Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells
in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high ...