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dc.contributor.authorCrespo-Piazuelo, Daniel
dc.contributor.authorMigura-Garcia, Lourdes
dc.contributor.authorEstellé, Jordi
dc.contributor.authorCriado-Mesas, Lourdes
dc.contributor.authorRevilla, Manuel
dc.contributor.authorCastelló, Anna
dc.contributor.authorMuñoz, María
dc.contributor.authorGarcía-Casco, Juan M.
dc.contributor.authorFernández, Ana I.
dc.contributor.authorBallester, Maria
dc.contributor.authorFolch, Josep M.
dc.contributor.otherProducció Animalca
dc.date.accessioned2019-09-12T07:04:32Z
dc.date.available2019-09-12T07:04:32Z
dc.date.issued2019-06-19
dc.identifier.citationCrespo-Piazuelo, Daniel, Lourdes Migura-Garcia, Jordi Estellé, Lourdes Criado-Mesas, Manuel Revilla, Anna Castelló, and María Muñoz et al. 2019. "Association Between The Pig Genome And Its Gut Microbiota Composition". Scientific Reports 9 (1). Springer Science and Business Media LLC. doi:10.1038/s41598-019-45066-6.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/481
dc.description.abstractThe gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess the role of the host genome in the modulation of the microbiota composition in pigs. Gut microbiota compositions were estimated through sequencing the V3-V4 region of the 16S rRNA gene from rectal contents of 285 pigs. A total of 1,261 operational taxonomic units were obtained and grouped in 18 phyla and 101 genera. Firmicutes (45.36%) and Bacteroidetes (37.47%) were the two major phyla obtained, whereas at genus level Prevotella (7.03%) and Treponema (6.29%) were the most abundant. Pigs were also genotyped with a high-throughput method for 45,508 single nucleotide polymorphisms that covered the entire pig genome. Subsequently, genome-wide association studies were made among the genotypes of these pigs and their gut microbiota composition. A total of 52 single-nucleotide polymorphisms distributed in 17 regions along the pig genome were associated with the relative abundance of six genera; Akkermansia, CF231, Phascolarctobacterium, Prevotella, SMB53, and Streptococcus. Our results suggest 39 candidate genes that may be modulating the microbiota composition and manifest the association between host genome and gut microbiota in pigs.ca
dc.format.extent11ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAssociation between the pig genome and its gut microbiota compositionca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO-FEDER/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2014-56369-C2-2-R/ES//Validación genética y funcional de QTLS, genes y redes génicas y estudio del efecto del microbioma sobre crecimiento, deposición de grasa y calidad de carne en porcino. S2/ca
dc.relation.projectIDMINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/Genómica funcional, biología de sistemas y microbiomica aplicadas a la identificación de reguladores genéticos del crecimiento, engrasamiento y calidad de la carne en porcino/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1038/s41598-019-45066-6ca
dc.contributor.groupGenètica i Millora Animalca
dc.contributor.groupSanitat Animalca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/