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A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
(BMC, 2020-06-05)
Background
Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could ...
Short Communication: The biological value of transition milk: analyses of Immunoglobulin G, IGF-I and Lactoferrin in primiparous and multiparous dairy cows
(Elsevier, 2023-05-24)
Colostrum (the first mammary gland secretion after calving) is known to contain high concentrations of nutrients as well as bioactive substances (including immunoglobulins, growth factors, and antimicrobial ...
Immunomodulation Evidence of Nanostructured Recombinant Proteins in Salmonid Cells
(MDPI, 2024-03-09)
Recent studies have demonstrated that immune-related recombinant proteins can enhance immune function, increasing host survival against infectious diseases in salmonids. This research evaluated inclusion ...
Effects of Flavonoids Extracted from Citrus aurantium on Performance, Behavior, and Rumen Gene Expression in Holstein Bulls Fed with High-Concentrate Diets in Pellet Form
(MDPI, 2021-05-13)
Flavonoid supplementation may modify the behavior and rumen inflammatory response of fattening bulls, and this could be related to the concentrate presentation (mash or pellet) form. In the present ...
Citrus Flavonoids Supplementation as an Alternative to Replace Zinc Oxide in Weanling Pigs’ Diets Minimizing the Use of Antibiotics
(MDPI, 2023-03-07)
Since citrus flavonoids have antioxidant and anti-inflammatory properties, it was hypothesized that these compounds would become a suitable alternative to the use of therapeutic doses of zinc oxide at ...
Lactiplantibacillus plantarum: a new example of inclusion body producing bacteria
(BMC, 2023-06-09)
Background
Lactic Acid Bacteria such as Lactococcus lactis, Latilactobacillus sakei (basonym: Lactobacillus sakei) and Lactiplantibacillus plantarum (basonym: Lactobacillus plantarum) have gained ...
A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins
(MDPI, 2023-03-26)
Antibiotic resistance has exponentially increased during the last years. It is necessary to develop new antimicrobial drugs to prevent and treat infectious diseases caused by multidrug- or extensively-drug ...
Exploring the use of leucine zippers for the generation of a new class of inclusion bodies for pharma and biotechnological applications
(BMC, 2020-09-04)
Background
Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been ...
In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics
(MDPI, 2020-12-17)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to ...
Getting value from the waste: recombinant production of a sweet protein by Lactococcus lactis grown on cheese whey
(BioMed Central, 2018-08-15)
Background
Recent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of ...