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Effect of metritis on endometrium tissue transcriptome during puerperium in Holstein lactating cows
(Elsevier, 2018-09-15)
The objective of this prospective cohort study was to evaluate the effect of parity and uterine healthstatus postpartum on the gene expression profile of the endometrium early post-partum. Twenty-fourHolstein ...
The Potential of Metalloproteinase-9 Administration to Accelerate Mammary Involution and Boost the Immune System at Dry-Off
(MDPI, 2021-11-30)
The dry period is decisive for the milking performance of dairy cows. The promptness of
mammary gland involution at dry-off affects not only the productivity in the next lactation, but also
the risk ...
Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle
(Frontiers Media, 2018-06-21)
Metritis affects up to 40% of dairy cows and it is usually treated with antibiotics. In
spite of their advantages, there is an increased concern about antibiotic resistance
leading to the research of ...
The future of recombinant host defense peptides
(BMC, 2022-12-21)
The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities ...
Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
(BMC, 2022-05-09)
The growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the antimicrobial peptides produced by innate immunity, ...
Design strategies for positively charged endolysins: Insights into Artilysin development
(Elsevier, 2023-09-06)
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development of novel antibacterial agents. ...
Potential of MMP-9 based nanoparticles at optimizing the cow dry period: pulling apart the effects of MMP-9 and nanoparticles
(Nature Research, 2020-07-09)
The cow dry period is a non-milking interval where the mammary gland involutes and regenerates
to guarantee an optimal milk production in the subsequent lactation. Important bottlenecks such
as the ...
Antibiofilm surfaces based on the immobilization of a novel recombinant antimicrobial multidomain protein using self-assembled monolayers
(Royal Society of Chemistry, 2023-04-13)
The constant increase of microorganisms resistant to antibiotics has been classified as a global health emergency, which is especially challenging when biofilms are formed. Herein, novel biofunctionalized ...
Supplementing Citrus aurantium Flavonoid Extract in High-Fat Finishing Diets Improves Animal Behavior and Rumen Health and Modifies Rumen and Duodenum Epithelium Gene Expression in Holstein Bulls
(MDPI, 2022-08-03)
One hundred and forty-six bulls (178.2 ± 6.64 kg BW and 146.0 ± 0.60 d of age) were randomly allocated to one of eight pens and assigned to control (C) or citrus flavonoid (BF) treatments (Citrus ...
Quality comparison of recombinant soluble proteins and proteins solubilized from bacterial inclusion bodies
(Elsevier, 2022-09-20)
Recombinant protein production in bacteria is often accompanied by the formation of aggregates, known as inclusion bodies (IBs). Although several strategies have been developed to minimize protein ...