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Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver
(Frontiers Media, 2023-09-14)
C-reactive protein (CRP) is an evolutionary highly conserved protein. Like humans, CRP acts as a major acute phase protein in pigs. While CRP regulatory mechanisms have been extensively studied in humans, ...
A compendium of genetic regulatory effects across pig tissues
(Nature Research, 2024-01-04)
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic ...
Identification of transcriptional regulatory variants in pig duodenum, liver, and muscle tissues
(Oxford University Press, 2023-06-24)
Background
In humans and livestock species, genome-wide association studies (GWAS) have been applied to study the association between variants distributed across the genome and a phenotype of interest. ...
Genetic architecture of innate and adaptive immune cells in pigs
(Frontiers Media, 2023-02-06)
Pig industry is facing new challenges that make necessary to reorient breeding programs to produce more robust and resilient pig populations. The aim of the present work was to study the genetic determinism ...
PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs
(Oxford University Press, 2023-11-13)
To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and ...
Genomic architecture of carcass and pork traits and their association with immune capacity
(Elsevier, 2023-11-28)
Carcass and pork traits have traditionally been considered of prime importance in pig breeding programmes. However, the changing conditions in modern farming, coupled with antimicrobial resistance issues, ...
A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs
(Frontiers Media, 2021-11-26)
In recent years, the increase in awareness of antimicrobial resistance together with the societal demand of healthier meat products have driven attention to health-related traits in livestock production. ...
Expression analysis of candidate genes for fatty acid composition in adipose tissue and identifcation of regulatory regions
(Nature Research, 2018-02-01)
The aim of this work was to study the genetic basis of the backfat expression of lipid-related genes
associated with meat quality traits in pigs. We performed a genome-wide association study with ...
Indel detection from Whole Genome Sequencing data and association with lipid metabolism in pigs
(Public Library of Science, 2019-06-27)
The selection in commercial swine breeds for meat-production efficiency has been increasing among the past decades, reducing the intramuscular fat content, which has changed the sensorial and technological ...
Copy Number Variation on ABCC2-DNMBP Loci Affects the Diversity and Composition of the Fecal Microbiota in Pigs
(American Society for Microbiology, 2023-05-31)
Genetic variation in the pig genome partially modulates the composition of porcine gut microbial communities. Previous studies have been focused on the association between single nucleotide polymorphisms ...