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Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins
(Nature Research, 2021-12-10)
Combining several innate immune peptides into a single recombinant antimicrobial and immunomodulatory polypeptide has been recently demonstrated. However, the versatility of the multidomain design, the ...
The biological potential hidden in inclusion bodies
(MDPI, 2020-02-15)
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein ...
Effect of dietary seaweed (Ascophyllum nodosum) supplementation on milk mineral concentrations, transfer efficiency, and hematological parameters in lactating Holstein cows
(Elsevier, 2023-05-18)
This study investigated the effect of feeding seaweed (Ascophyllum nodosum) to dairy cows on milk mineral concentrations, feed-to-milk mineral transfer efficiencies and hematological parameters. Lactating ...
Current Knowledge on the Transportation by Road of Cattle, including Unweaned Calves
(MDPI, 2023-11-01)
Transport conditions have the potential to alter the physiological responses of animals to the psychological or physical stress of transport. Transportation may introduce multiple physical and psychological ...
Prevalence and lameness-associated risk factors in Alberta feedlot cattle
(Oxford University Press, 2019-03-13)
Lameness in cattle is a health and welfare concern; however, limited information is available on risk factors and the relationship between lameness and common diseases like bovine respiratory disease ...
Effect of metritis on endometrium tissue transcriptome during puerperium in Holstein lactating cows
(Elsevier, 2018-09-15)
The objective of this prospective cohort study was to evaluate the effect of parity and uterine healthstatus postpartum on the gene expression profile of the endometrium early post-partum. Twenty-fourHolstein ...
Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle
(Frontiers Media, 2018-06-21)
Metritis affects up to 40% of dairy cows and it is usually treated with antibiotics. In
spite of their advantages, there is an increased concern about antibiotic resistance
leading to the research of ...
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
(BMC, 2020-06-05)
Background
Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could ...
The future of recombinant host defense peptides
(BMC, 2022-12-21)
The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities ...