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Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs
(Nature Research, 2017-04-19)
In the present study, liver co-expression networks and expression Genome Wide Association Study
(eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional
regulatory ...
The PHH-1V HIPRA vaccine: a new tool in the vaccination strategy against COVID-19
(Sociedad Española de Quimioterapia, 2023-06-12)
Objectives. Vaccination against SARS-CoV-2 is essential
to mitigate the personal, social and global impact of the coronavirus disease (COVID-19) as we move from a pandemic to
an endemic phase. Vaccines ...
Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report
(Oxford University Press, 2021-06-23)
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections have been reported; however, most cases are milder than the primary infection. We report the first case of a ...
Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
(Elsevier, 2024-03)
Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells
in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high ...
Clinical, Pathological and Virological Outcomes of Tissue-Homogenate-Derived and Cell-Adapted Strains of Porcine Epidemic Diarrhea Virus (PEDV) in a Neonatal Pig Model
(MDPI, 2023-12-27)
Porcine epidemic diarrhea virus (PEDV) is characterized by diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Two distinct genogroups, S-INDEL (G1a, G1b) and
non-S INDEL ...
A mutation in the melon Vacuolar Protein Sorting 41prevents systemic infection of Cucumber mosaic virus
(Nature Research, 2017-09-05)
In the melon exotic accession PI 161375, the gene cmv1, confers recessive resistance to Cucumber
mosaic virus (CMV) strains of subgroup II. cmv1 prevents the systemic infection by restricting the ...
A global analysis of CNVs in swine using whole genome sequence data and association analysis with fatty acid composition and growth traits
(Public Library of Science, 2017-05-04)
Copy number variations (CNVs) are important genetic variants complementary to SNPs, and can be considered as biomarkers for some economically important traits in domestic animals. In the present study, ...
Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge
(Public Library of Science, 2019-03-01)
Swine influenza viruses (SIVs), the causal agents of swine influenza, are not only important to control due to the economic losses in the swine industry, but also can be pandemic pathogens. Vaccination ...
Neuropathogenesis of a highly pathogenic avian influenza virus (H7N1) in experimentally infected chickens
(BMC, 2011-10-07)
In order to understand the mechanism of neuroinvasion of a highly pathogenic avian influenza virus (HPAIV) into
the central nervous system (CNS) of chickens, specific pathogen free chickens were ...