Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
Visualitza/Obre
Autor/a
Hendriksen, Rene S.
Munk, Patrick
Njage, Patrick
van Bunnik, Bram
McNally, Luke
Lukjancenko, Oksana
Röder, Timo
Nieuwenhuijse, David
Pedersen, Susanne Karlsmose
Kjeldgaard, Jette
Kaas, Rolf S.
Clausen, Philip Thomas Lanken Conradsen
Vogt, Josef Korbinian
Leekitcharoenphon, Pimlapas
van de Schans, Milou G.M.
Zuidema, Tina
de Roda Husman, Ana Maria
Rasmussen, Simon
Petersen, Bent
Global Sewage Surveillance project consortium
Data de publicació
2019-03-08ISSN
2041-1723
Resum
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
12
Publicat per
Nature Research
Publicat a
Nature Communications
Citació
Hendriksen, Rene S., Patrick Munk, Patrick Njage, Bram van Bunnik, Luke McNally, Oksana Lukjancenko, and Timo Röder et al. 2019. "Global Monitoring Of Antimicrobial Resistance Based On Metagenomics Analyses Of Urban Sewage". Nature Communications 10 (1). Springer Nature. doi:10.1038/s41467-019-08853-3.
Programa
Sanitat Animal
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