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Conserved HA-peptides expressed along with flagellin in Trichoplusia ni larvae protects chicken against intranasal H7N1 HPAIV challenge
dc.contributor.author | Sisteré-Oró, Marta | |
dc.contributor.author | Martínez-Pulgarín, Susana | |
dc.contributor.author | Solanes, David | |
dc.contributor.author | Veljkovic, Veljko | |
dc.contributor.author | López-Serrano, Sergi | |
dc.contributor.author | Córdoba, Lorena | |
dc.contributor.author | Cordón, Ivan | |
dc.contributor.author | Escribano, José M. | |
dc.contributor.author | Darji, Ayub | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2020-04-27T06:59:39Z | |
dc.date.available | 2020-04-27T06:59:39Z | |
dc.date.issued | 2019-11-14 | |
dc.identifier.citation | Sisteré-Oró, Marta, Susana Martínez-Pulgarín, David Solanes, Veljko Veljkovic, Sergi López-Serrano, Lorena Córdoba, Ivan Cordón, José M. Escribano, and Ayub Darji. 2020. "Conserved HA-Peptides Expressed Along With Flagellin In Trichoplusia Ni Larvae Protects Chicken Against Intranasal H7N1 HPAIV Challenge". Vaccine 38 (3): 416-422. Elsevier BV. doi:10.1016/j.vaccine.2019.11.006. | ca |
dc.identifier.issn | 0264-410X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/747 | |
dc.description.abstract | The immunization of poultry where H5 and H7 influenza viruses (IVs) are endemic is one of the strategies to prevent unexpected zoonoses. Our group has been focused on conserved HA-epitopes as potential vaccine candidates to obtain multivalent immune responses against distinct IV subtypes. In this study, two conserved epitopes (NG-34 and CS-17) fused to flagellin were produced in a Baculovirus platform based on Trichoplusia ni larvae as living biofactories. Soluble extracts obtained from larvae expressing "flagellin-NG34/CS17 antigen" were used to immunize chickens and the efficacy of the vaccine was evaluated against a heterologous H7N1 HPAIV challenge in chickens. The flagellin-NG34/CS17 vaccine protected the vaccinated chickens and blocked viral shedding orally and cloacally. Furthermore, no apparent clinical signs were monitored in 10/12 vaccinated individuals. The mechanism of protection conferred is under investigation. | ca |
dc.format.extent | 7 | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | Vaccine | ca |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Conserved HA-peptides expressed along with flagellin in Trichoplusia ni larvae protects chicken against intranasal H7N1 HPAIV challenge | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2013-48923-C2-2-R/ES/Nuevas estrategias vacunales frente a enfermedades víricas ganaderas empleando pseudopartículas virales modificadas/ | ca |
dc.relation.projectID | EC/H2020/730964/EU/European Vaccine Research and Development Infrastructure/TRANSVAC2 | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1016/j.vaccine.2019.11.006 | ca |
dc.contributor.group | Sanitat Animal | ca |
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