Networks of inbreeding coefficients in a selected population of rabbits
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Rodríguez‐Ramilo, Silvia T.
Sánchez, Juan P.
The correlation between pedigree and genomic‐based inbreeding coefficients is usually discussed in the literature. However, some of these correlations could be spurious. Using partial correlations and information theory, it is possible to distinguish a significant association between two variables which is independent from associations with a third variable. The objective of this study is to implement partial correlations and information theory to assess the relationship between different inbreeding coefficients using a selected population of rabbits. Data from pedigree and genomic information from a 200K SNP chip were available. After applying filtering criteria, the data set comprised 437 animals genotyped for 114,604 autosomal SNP. Fifteen pedigree‐ and genome‐based inbreeding coefficients were estimated and used to build a network. Recent inbreeding coefficient based on runs of homozygosity had 9 edges linking it with different inbreeding coefficients. Partial correlations and information theory approach allowed to infer meaningful associations between inbreeding coefficients and highlighted the importance of the recent inbreeding based on runs of homozygosity, but a good proxy of it could be those pedigree‐based definitions reflecting recent inbreeding.
575 - Genètica general. Citogenètica general. Immunogenètica. Evolució. Filogènia
59 - Zoologia
619 - Veterinària
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Is part of
Journal of Animal Breeding and Genetics
Rodríguez‐Ramilo, Silvia T., Antonio Reverter, Juan P. Sánchez, Jesus Fernández, Maria Velasco‐Galilea, Olga González, and Miriam Piles. 2020. "Networks Of Inbreeding Coefficients In A Selected Population Of Rabbits". Journal Of Animal Breeding And Genetics 137 (6): 599-608. doi:10.1111/jbg.12500.
Grant agreement number
EC/H2020/633531/EU/Adapting the feed, the animal and the feeding techniques to improve the efficiency and sustainability of monogastric livestock production systems/Feed-a-Gene
MINECO/Programa Estatal de I+D+I orientada a los Retos de la Sociedad/RTA2014-00015-C02-01/ES/Mejora de la eficiencia alimentaria en cerdos y conejos. Determinismo genético y estrategias de selección/
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