Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation
Visualitza/Obre
Autor/a
Lund, Peter A.
De Biase, Daniela
Liran, Oded
Scheler, Ott
Pereira Mira, Nuno
Cetecioglu, Zeynep
Noriega Fernández, Estefanía
Bover-Cid, Sara
Hall, Rebecca
Sauer, Michael
O’Byrne, Conor
Data de publicació
2020-09-24ISSN
1664-302X
Resum
Microbes from the three domains of life, Bacteria, Archaea, and Eukarya, share the need to sense and respond to changes in the external and internal concentrations of protons. When the proton concentration is high, acidic conditions prevail and cells must respond appropriately to ensure that macromolecules and metabolic processes are sufficiently protected to sustain life. While, we have learned much in recent decades about the mechanisms that microbes use to cope with acid, including the unique challenges presented by organic acids, there is still much to be gained from developing a deeper understanding of the effects and responses to acid in microbes. In this perspective article, we survey the key molecular mechanisms known to be important for microbial survival during acid stress and discuss how this knowledge might be relevant to microbe-based applications and processes that are consequential for humans. We discuss the research approaches that have been taken to investigate the problem and highlight promising new avenues. We discuss the influence of acid on pathogens during the course of infections and highlight the potential of using organic acids in treatments for some types of infection. We explore the influence of acid stress on photosynthetic microbes, and on biotechnological and industrial processes, including those needed to produce organic acids. We highlight the importance of understanding acid stress in controlling spoilage and pathogenic microbes in the food chain. Finally, we invite colleagues with an interest in microbial responses to low pH to participate in the EU-funded COST Action network called EuroMicropH and contribute to a comprehensive database of literature on this topic that we are making publicly available.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
663/664 - Aliments i nutrició. Enologia. Olis. Greixos
Pàgines
8
Publicat per
Frontiers Media
Publicat a
Frontiers in Microbiology
Citació
Lund, Peter A., Daniela De Biase, Oded Liran, Ott Scheler, Nuno Pereira Mira, Zeynep Cetecioglu, and Estefanía Noriega Fernández et al. 2020. "Understanding How Microorganisms Respond To Acid Ph Is Central To Their Control And Successful Exploitation". Frontiers In Microbiology 11. doi:10.3389/fmicb.2020.556140.
Número de l'acord de la subvenció
EC/COST/CA18113/EU/Understanding and exploiting the impacts of low pH on micro-organisms/EuroMicropH
Programa
Funcionalitat i Seguretat Alimentària
Aquest element apareix en la col·lecció o col·leccions següent(s)
- ARTICLES CIENTÍFICS [2811]
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/