Transmission of Similar Mcr-1 Carrying Plasmids among Different Escherichia coli Lineages Isolated from Livestock and the Farmer
Visualitza/Obre
Autor/a
Viñes, Joaquim
Cuscó, Anna
Alvarez, Julio
Saez-Llorente, Jose Luis
Rosàs-Rodoreda, Montserrat
Francino, Olga
Migura-Garcia, Lourdes
Data de publicació
2021-03-17ISSN
2079-6382
Resum
Colistin use has mostly been stopped in human medicine, due to its toxicity. However, nowadays, it still is used as a last-resort antibiotic to treat hospital infections caused by multi-drug resistant Enterobacteriaceae. On the contrary, colistin has been used in veterinary medicine until recently. In this study, 210 fecal samples from pigs (n = 57), calves (n = 152), and the farmer (n = 1) were collected from a farm where E. coli harboring mcr-1-mcr-3 was previously detected. Samples were plated, and mcr-genes presence was confirmed by multiplex-PCR. Hybrid sequencing which determined the presence and location of mcr-1, other antibiotic resistance genes, and virulence factors. Eighteen colistin resistant isolates (13 from calves, four from pigs, and one from the farmer) contained mcr-1 associated with plasmids (IncX4, IncI2, and IncHI2), except for two that yielded mcr-1 in the chromosome. Similar plasmids were distributed in different E. coli lineages. Transmission of mcr-1 to the farmer most likely occurred by horizontal gene transfer from E. coli of calf origin, since plasmids were highly similar (99% coverage, 99.97% identity). Moreover, 33 virulence factors, including stx2 for Shiga toxin E. coli (STEC) were detected, highlighting the role of livestock as a reservoir of pathotypes with zoonotic potential.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
13
Publicat per
MDPI
Publicat a
Antibiotics
Citació
Viñes, Joaquim, Anna Cuscó, Sebastian Napp, Julio Alvarez, Jose Luis Saez-Llorente, Montserrat Rosàs-Rodoreda, Olga Francino, and Lourdes Migura-Garcia. 2021. "Transmission Of Similar Mcr-1 Carrying Plasmids Among Different Escherichia Coli Lineages Isolated From Livestock And The Farmer". Antibiotics 10 (3): 313. doi:10.3390/antibiotics10030313.
Número de l'acord de la subvenció
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTI2018-095586-B-C22/ES/Optimization of diagnosis and treatment of postweaning diarrheas in pigs: towards a rational use of antibiotics/
Programa
Sanitat Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
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Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/