A toxicokinetic study reflecting the absorption, distribution, metabolism and excretion of deoxynivalenol in broiler chickens
Visualitza/Obre
Data de publicació
2021-06-26ISSN
0971-2119
Resum
To identify the specific biomarkers of exposure of DON in chickens, a toxicokinetic study was performed via oral or intravenous application of deoxynivalenol (DON). Doses of 0.75 and 2.25 mg DON/kg of body weight (BW) were administrated intravenously or orally to the chickens. Next, blood samples were ollected at several time points and plasma was obtained. Liquid chromatography–tandem mass-spectrometry (LC–MS/MS) was used to quantify plasma levels of DON and its metabolite DON-3-sulphate (DON-3S). A non-compartmental analysis was performed to study the main toxicokinetic parameters after intravenous or oral application of the toxin. Regarding oral administration, DON plasma level was below the limit of detection (LOD) of the method (1.5 ng/mL) and DON-3S could not be identified. After intravenous administration of DON at 0.75 and 2.25 mg DON/kg BW, the elimination half-life was 57.1 and 47.7 min, respectively, indicating the rapid elimination of DON. The metabolite DON-3S was found in plasma of broilers exposed to DON intravenously. The absence of DON in chicken plasma after oral bolus application suggests the low absorption of this mycotoxin. The presence of DON-3S in plasma indicates that this metabolite could be the appropriate biomarker of DON exposure in chickens.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Pàgines
6
Publicat per
Taylor & Francis Open Access
Publicat a
Journal of Applied Animal Research
Citació
Riahi, Insaf, Antonio J. Ramos, Anna Maria Pérez-Vendrell, and Virginie Marquis. 2021. "A Toxicokinetic Study Reflecting The Absorption, Distribution, Metabolism And Excretion Of Deoxynivalenol In Broiler Chickens". Journal Of Applied Animal Research 49 (1): 284-288. doi:10.1080/09712119.2021.1946403.
Programa
Nutrició Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
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