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β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts
dc.contributor.author | Alkassar, Mounira | |
dc.contributor.author | Reverté, Jaume | |
dc.contributor.author | Fragoso, Alex | |
dc.contributor.author | Torréns, Mabel | |
dc.contributor.author | Klijnstra, Mirjam | |
dc.contributor.author | Gerssen, Arjen | |
dc.contributor.author | Diogène, Jorge | |
dc.contributor.author | Campàs, Mònica | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2024-04-26T09:44:00Z | |
dc.date.issued | 2024-04-16 | |
dc.identifier.citation | Alkassar, Mounira, Jaume Reverté, Alex Fragoso, Mabel Torréns, Mirjam D. Klijnstra, Arjen Gerssen, Jorge Diogène, and Mònica Campàs. 2024. “Β-cyclodextrin Polymer as Tetrodotoxins Scavenger in Oyster Extracts.” Microchemical Journal, 110585. https://doi.org/10.1016/j.microc.2024.110585. | ca |
dc.identifier.issn | 0026-265X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2951 | |
dc.description.abstract | Tetrodotoxins (TTXs) are potent marine neurotoxins involved in poisoning cases in humans after consumption of some marine organisms. A cell-based assay (CBA) providing toxicological information is a commonly used method for their detection because of its high sensitivity. However, matrix effects may interfere in the CBA. In this work, five insoluble cyclodextrin polymers, with different chemicals structures (βCDP-14-DS2, βCDP-13-DS2, βCDP-13-DS4, βCDP-14-DS4 and βCDP-N-DS5) have been investigated as novel clean-up materials for oyster extracts containing TTXs. The best recoveries have been achieved with βCDP-14-DS2 (∼100 %), which allowed exposing cells to 27-fold higher oyster matrix concentrations and decreased the LOQ down to 46 µg equiv. TTX/kg. Then, the applicability of this strategy has been demonstrated with oyster extracts from The Netherlands and comparing the results with immunoassay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). This clean-up strategy combined with CBA could be implemented for TTXs detection in monitoring programs to ensure seafood safety. | ca |
dc.description.sponsorship | This research was funded by the Ministerio de Ciencia e Innovación (MICIN) and the Agencia Estatal de Investigación (AEI) through the CELLECTRA (PID2020-112976RB-C21 and PID2020-112976RB-C22) project and by the European Commission through the BLUESHELLFISH (HORIZON-MSCA-101086234) project. Mounira Alkassar acknowledges MICIN and AEI for her PhD grant (PRE2019-088181). Jaume Reverté acknowledges IRTA for his PhD grant (CPI0422). The authors also acknowledge support from CERCA Program/Generalitat de Catalunya. | ca |
dc.format.extent | 27 | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | Microchemical Journal | ca |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/embargoedAccess | |
dc.date.embargoEnd | 2026-04-16T02:00:00Z | |
dc.embargo.terms | 24 mesos | ca |
dc.relation.projectID | MC/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112976RB-C21/ES/Herramientas biotecnológicas basadas en células y receptores para la detección de ciguatoxinas y tetrodotoxinas/CELLECTRA | ca |
dc.relation.projectID | MC/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112976RB-C22/ES/Herramientas biotecnológicas basadas en células y aptámeros para la detección de ciguatoxinas y tetrodotoxinas/CELLECTRA | ca |
dc.relation.projectID | EC/HORIZON/101086234/EU/Solutions to prevent and mitigate the impacts of HABs in Aquaculture and Fisheries, in the context of global warming/BlueShellfish | ca |
dc.subject.udc | 574 | ca |
dc.identifier.doi | https://doi.org/10.1016/j.microc.2024.110585 | ca |
dc.contributor.group | Aigües Marines i Continentals | ca |
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