Pathogenesis and transmissibility of highly (H7N1) and low (H7N9) pathogenic avian influenza virus infection in red-legged partridge (Alectoris rufa)
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Author
Bertran, Kateri
Pérez-Ramírez, Elisa
Busquets, Núria
Dolz, Roser
Ramis, Antonio
Abad, Francesc Xavier
Valle, Rosa
Chaves, Aida
Vergara-Alert, Júlia
Barral, Marta
Höfle, Ursula
Majó, Natàlia
Publication date
2011-02-07ISSN
0928-4249
Abstract
An experimental infection with highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza
virus (LPAIV) was carried out in red-legged partridges (Alectoris rufa) in order to study clinical signs, gross and
microscopic lesions, and viral distribution in tissues and viral shedding. Birds were infected with a HPAIV subtype
H7N1 (A/Chicken/Italy/5093/1999) and a LPAIV subtype H7N9 (A/Anas crecca/Spain/1460/2008). Uninoculated birds
were included as contacts in both groups. In HPAIV infected birds, the first clinical signs were observed at 3 dpi,
and mortality started at 4 dpi, reaching 100% at 8 dpi. The presence of viral antigen in tissues and viral shedding
were confirmed by immunohistochemistry and quantitative real time RT-PCR (qRRT-PCR), respectively, in all birds
infected with HPAIV. However, neither clinical signs nor histopathological findings were observed in LPAIV infected
partridges. In addition, only short-term viral shedding together with seroconversion was detected in some LPAIV
inoculated animals. The present study demonstrates that the red-legged partridge is highly susceptible to the
H7N1 HPAIV strain, causing severe disease, mortality and abundant viral shedding and thus contributing to the
spread of a potential local outbreak of this virus. In contrast, our results concerning H7N9 LPAIV suggest that the
red-legged partridge is not a reservoir species for this virus.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
9
Publisher
BMC
Is part of
Veterinary Research
Citation
Bertran, Kateri, Elisa Pérez-Ramírez, Núria Busquets, Roser Dolz, Antonio Ramis, Ayub Darji, Francesc Xavier Abad, et al. 2011. “Pathogenesis and Transmissibility of Highly (H7N1) and Low (H7N9) Pathogenic Avian Influenza Virus Infection in Red-legged Partridge (Alectoris Rufa).” Veterinary Research 42 (1): 24. doi: 10.1186/1297-9716-42-24
Grant agreement number
INIA/Programa nacional de recursos y tecnologías agroalimentarias/FAU2006-00019-C03-01/ES/Ensayos de persistencia ambiental del virus y estudio de la inmunopatogenia en aves criadas en regímenes no intensivos/
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2838]
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