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Removal of the Erns RNase Activity and of the 39 Untranslated Region Polyuridine Insertion in a Low-Virulence Classical Swine Fever Virus Triggers a Cytokine Storm and Lethal Disease
(American Society for Microbiology, 2022-06-27)
In this study, we assessed the potential synergistic effect of the Erns RNase activity and the poly-U insertion in the 3′ untranslated region (UTR) of the low-virulence classical swine fever virus (CSFV) ...
Investigation of chronic and persistent classical swine fever infections under field conditions and their impact on vaccine efficacy
(BMC, 2019-07-15)
Background: Recent studies have hypothesized that circulation of classical swine fever virus (CSFV) variants when the immunity induced by the vaccine is not sterilizing might favour viral persistence. ...
Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs
(MDPI, 2021-10-02)
Classical swine fever virus (CSFV) causes a viral disease of high epidemiological and
economical significance that affects domestic and wild swine. Control of the disease in endemic
countries is based ...
A Polyuridine Insertion in the 3′ Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets
(American Society for Microbiology, 2020-01-06)
Low-virulence classical swine fever virus (CSFV) strains make CSF eradication particularly difficult. Few data are available on the molecular determinants of CSFV virulence. The aim of the present study ...
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs
(Taylor & Francis Open Access, 2021-08-02)
The prevalence of low virulence classical swine fever virus (CSFV) strains makes viral eradication difficult in endemic countries. However, the determinants for natural CSFV attenuation and persistence ...
The new emerging ovine pestivirus can infect pigs and confers strong protection against classical swine fever virus
(Wiley, 2021-04-25)
Several emerging pestiviruses have been reported lately, some of which have proved to cause disease. Recently, a new ovine pestivirus (OVPV), isolated from aborted lambs, with high genetic identity to ...
Early and Solid Protection Afforded by the Thiverval Vaccine Provides Novel Vaccination Alternatives Against Classical Swine Fever Virus
(MDPI, 2021-05-06)
Classical swine fever virus (CSFV) remains a challenge for the porcine industry. Inefficient
vaccination programs in some endemic areas may have contributed to the emergence of low and
moderate virulence ...
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
(MDPI, 2022-09-02)
Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G ...
Classical swine fever virus: the past, present and future
(Elsevier, 2020-09-06)
Classical swine fever (CSF) is among the most relevant viral epizootic diseases of swine. Due to its severe economic impact, CSF is notifiable to the world organisation for animal health. Strict control ...
Foetal Immune Response Activation and High Replication Rate during Generation of Classical Swine Fever Congenital Infection
(MDPI, 2020-04-14)
Classical swine fever virus (CSFV) induces trans-placental transmission and congenital viral persistence; however, the available information is not updated. Three groups of sows were infected at ...