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Hippocampal neurogenesis and Arc expression are enhanced in high-fat fed prepubertal female pigs by a diet including omega-3 fatty acids and Bifidobacterium breve CECT8242
(Springer, 2023-05-06)
Obesity during childhood has become a pandemic disease, mainly caused by a diet rich in sugars and fatty acids. Among other negative effects, these diets can induce cognitive impairment and reduce ...
Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring’s Metabolic Profile in a Swine Model
(MDPI, 2024-01-17)
Limited nutrient supply to the fetus results in physiologic and metabolic adaptations that have unfavorable consequences in the offspring. In a swine animal model, we aimed to study the effects of ...
High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage
(MDPI, 2024-01-26)
Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by ...
Gut barrier-microbiota imbalances in early life lead to higher sensitivity to inflammation in a murine model of C-section delivery
(BMC, 2023-07-03)
Background Most interactions between the host and its microbiota occur at the gut barrier, and primary colonizers
are essential in the gut barrier maturation in the early life. The mother–ofspring ...
Short Communication: Comparing the microbiota diversity from the core, middle part and rind of six Spanish commercial goat cheeses
(Elsevier, 2024-05-23)
The cheese core has a lower oxygen saturation and salinity and a higher acidity than the rind, but there is controversy about the incidence of such factors on the magnitude of microbial diversity. The ...
Expression-based GWAS identifies variants, gene interactions and key regulators affecting intramuscular fatty acid content and composition in porcine meat
(Nature Research, 2016-08-18)
The aim of this work is to better understand the genetic mechanisms determining two complex traits
affecting porcine meat quality: intramuscular fat (IMF) content and its fatty acid (FA) composition. ...
Copy Number Variation on ABCC2-DNMBP Loci Affects the Diversity and Composition of the Fecal Microbiota in Pigs
(American Society for Microbiology, 2023-05-31)
Genetic variation in the pig genome partially modulates the composition of porcine gut microbial communities. Previous studies have been focused on the association between single nucleotide polymorphisms ...
Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
(American Society for Microbiology, 2023-12-14)
The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate ...
Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis
(BMC, 2024-02-12)
Background
Intramuscular fat (IMF) content and its fatty acid (FA) composition are typically controlled by several genes, each with a small effect. In the current study, to pinpoint candidate genes and ...