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Now showing items 411-420 of 421
Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
(MDPI, 2024-05-17)
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to ...
Role of wild ruminants in the epidemiology of bluetongue virus serotypes 1, 4 and 8 in Spain
(BMC, 2011-07-23)
Although the importance of wild ruminants as potential reservoirs of bluetongue virus (BTV) has been suggested,
the role played by these species in the epidemiology of BT in Europe is still unclear. ...
Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2
(MDPI, 2024-05-09)
African swine fever (ASF) is a deadly disease of swine currently causing a worldwide
pandemic, leading to severe economic consequences for the porcine industry. The control of disease
spread is hampered ...
Neuropathogenesis of a highly pathogenic avian influenza virus (H7N1) in experimentally infected chickens
(BMC, 2011-10-07)
In order to understand the mechanism of neuroinvasion of a highly pathogenic avian influenza virus (HPAIV) into
the central nervous system (CNS) of chickens, specific pathogen free chickens were ...
Increase in Th17 and T-reg Lymphocytes and Decrease of IL22 Correlate with the Recovery Phase of Acute EAE IN Rat
(Public Library of Science, 2011-11-07)
Experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis, is characterised by
microglial activation and lymphocyte infiltration. Induction of EAE in Lewis rats ...
Exploring the Antiviral Potential of Natural Compounds against Influenza: A Combined Computational and Experimental Approach
(MDPI, 2024-04-30)
The influenza A virus nonstructural protein 1 (NS1), which is crucial for viral replication
and immune evasion, has been identified as a significant drug target with substantial potential to
contribute ...
Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae
(MDPI, 2024-05-23)
In this study, we pioneered an alternative technology for manufacturing subunit influenza
hemagglutinin (HA)-based vaccines. This innovative method involves harnessing the pupae of the
Lepidoptera ...
Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates
(Public Library of Science, 2015-08-06)
Interspecies transmission of prions is a well-established phenomenon, both experimentally and under field conditions. Upon passage through new hosts, prion strains have proven their capacity to change ...
Metatranscriptomics reveals metabolic adaptation and induction of virulence factors by Haemophilus parasuis during lung infection
(BMC, 2015-09-23)
Haemophilus parasuis is a common inhabitant of the upper respiratory tract of pigs, and the causative agent of Glässer’s disease. This disease is characterized by polyserositis and arthritis, produced ...
Inefficient Transmission of African Swine Fever Virus toSentinel Pigs from an Environment Contaminated byASFV-Infected Pigs under Experimental Conditions
(Wiley, 2024-01-18)
Knowledge about African swine fever virus (ASFV) transmission and its survival in the environment is mandatory to developrational control strategies and combat this serious disease in pigs. In this ...