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Lack of detection of Mycobacterium microti infection in wild rodents from a free‑ranging wild boar outbreak area
(Springer, 2023-10-18)
Wild small rodents are considered the natural reservoirs of Mycobacterium microti, a member of the Mycobacterium tuberculosis complex (MTBC) that can cause tuberculosis (TB) in humans and animals, as ...
Disease-specific changes in reelin protein and mRNA in neurodegenerative diseases
(MDPI, 2020-05-19)
Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during ...
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation
(Springer Nature, 2023-12-18)
Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that
contribute to these fates are described, the critical control points and ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Public Library of Science, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...
Protective effect of a polyvalent influenza DNA vaccine in pigs
(Elsevier, 2017-11-23)
Background: Influenza A virus in swine herds represents a major problem for the swine industry and poses a
constant threat for the emergence of novel pandemic viruses and the development of more effective ...
Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
(Public Library of Science, 2018-05-09)
Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that
causes large economic losses in livestock. Goats are particularly susceptible to TB and, in
endemic areas, vaccination ...
Anti-PD-L1 Immunotherapy of Chronic Virus Infection Improves Virus Control without Augmenting Tissue Damage by Fibrosis
(MDPI, 2024-05-17)
Immunotherapy with checkpoint inhibitors, albeit commonly used against tumors, is
still at its infancy against chronic virus infections. It relies on the reinvigoration of exhausted T
lymphocytes to ...
Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2
(MDPI, 2024-05-09)
African swine fever (ASF) is a deadly disease of swine currently causing a worldwide
pandemic, leading to severe economic consequences for the porcine industry. The control of disease
spread is hampered ...
Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates
(Public Library of Science, 2015-08-06)
Interspecies transmission of prions is a well-established phenomenon, both experimentally and under field conditions. Upon passage through new hosts, prion strains have proven their capacity to change ...