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Now showing items 11-20 of 26
Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle
(Frontiers Media, 2018-06-21)
Metritis affects up to 40% of dairy cows and it is usually treated with antibiotics. In
spite of their advantages, there is an increased concern about antibiotic resistance
leading to the research of ...
Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
(BMC, 2022-05-09)
The growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the antimicrobial peptides produced by innate immunity, ...
The future of recombinant host defense peptides
(BMC, 2022-12-21)
The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities ...
A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
(BMC, 2020-06-05)
Background
Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could ...
Antibiofilm surfaces based on the immobilization of a novel recombinant antimicrobial multidomain protein using self-assembled monolayers
(Royal Society of Chemistry, 2023-04-13)
The constant increase of microorganisms resistant to antibiotics has been classified as a global health emergency, which is especially challenging when biofilms are formed. Herein, novel biofunctionalized ...
Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins
(Nature Research, 2021-12-10)
Combining several innate immune peptides into a single recombinant antimicrobial and immunomodulatory polypeptide has been recently demonstrated. However, the versatility of the multidomain design, the ...
Potential of Oral Nanoparticles Containing Cytokines as Intestinal Mucosal Immunostimulants in Pigs: A Pilot Study
(MDPI, 2022-04-21)
Antimicrobial resistance is a global threat that is worryingly rising in the livestock sector.
Among the proposed strategies, immunostimulant development appears an interesting approach to
increase ...
CCL21-loaded 3D hydrogels for T cell expansion and differentiation
(Elsevier, 2020-08-13)
Recent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, ...
In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics
(MDPI, 2020-12-17)
Oligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to ...
Exploring the use of leucine zippers for the generation of a new class of inclusion bodies for pharma and biotechnological applications
(BMC, 2020-09-04)
Background
Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been ...