Now showing items 1-10 of 11
A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa
(National Academy of Sciences, 2021-03-09)
The primary task of a spermatozoon is to deliver its nuclear payload to the egg to form the next-generation zygote. With polyandry repeatedly evolving in the animal kingdom, however, sperm competition ...
Lineage-level divergence of copepod glycerol transporters and the emergence of isoform-specific trafficking regulation
(Nature Research, 2021-05-31)
Transmembrane conductance of small uncharged solutes such as glycerol typically occurs through aquaglyceroporins (Glps), which are commonly encoded by multiple genes in metazoan organisms. To date, ...
Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment
(The Company of Biologists, 2017-06-01)
The development of the pigmentation pattern in zebrafish is a tightly regulated process that depends on both the self-organizing properties of pigment cells and extrinsic cues from other tissues. Many ...
Auto-Adhesion Potential of Extraocular Aqp0 during Teleost Development
(Public Library of Science, 2016-05-06)
AQP0 water channels are the most abundant proteins expressed in the mammalian lens fiber membranes where they are essential for lens development and transparency. Unlike other aquaporin paralogs, mammalian ...
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
(Springer Nature, 2019-12-11)
Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type ...
Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis
(Nature Research, 2022-08-19)
In non-mammalian vertebrates, the molecular mechanisms involved in the transformation of haploid germ cells (HGCs) into spermatozoa (spermiogenesis) are largely unknown. Here, we investigated this process ...
Toward developing recombinant gonadotropin-based hormone therapies for increasing fertility in the flatfish Senegalese sole
(Public Library of Science, 2017-03-22)
Captive flatfishes, such as the Senegalese sole, typically produce very low volumes of sperm. This situation is particularly prevalent in the first generation (F1) of reared sole males, which limits the ...
Insect glycerol transporters evolved by functional co-option and gene replacement
(Nature Research, 2015-07-17)
Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess ...
Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility
(Nature Research, 2015-01-14)
Reactive oxygen species (ROS), particularly hydrogen peroxide (H2O2), cause oxidative cell damage and inhibit sperm function. In most oviparous fishes that spawn in seawater (SW), spermatozoa may be ...
The Lineage-Specific Evolution of Aquaporin Gene Clusters Facilitated Tetrapod Terrestrial Adaptation
(Public Library of Science, 2014-11-26)
A major physiological barrier for aquatic organisms adapting to terrestrial life is dessication in the aerial environment. This barrier was nevertheless overcome by the Devonian ancestors of extant ...