Comparison of Mycoplasma hyopneumoniae and porcine circovirus 2 commercial vaccines efficacy when applied separate or combined under experimental conditions
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Author
Sibila, M.
Guevara, G.
Cuadrado, R.
Pleguezuelos, P.
Pérez, D.
Pérez de Rozas, A.
Huerta, E.
Llorens, A.
Valero, O.
Pérez, M.
López, C.
Krejci, R.
Segalés, J.
Publication date
2020-05-04ISSN
2055-5660
Abstract
Background
Mycoplasma hyopneumoniae (Mhyo) and Porcine circovirus 2 (PCV-2) are two of the most significant infectious agents causing economic losses in the weaning to slaughter period. Due to their similar vaccination age, the objective of this study was to assess the efficacy of two already existing Mhyo (Hyogen®) and PCV-2 (Circovac®) vaccines when administered separately or combined (RTM) by means of Mhyo or PCV-2 experimental challenges.
Results
Seven groups of animals were included in the study, being three of them challenged with PCV-2, three with Mhyo and one composed of non-challenged, non-vaccinated pigs. Within each experimental challenge, non-vaccinated (NV) groups were compared with double vaccinated groups using the commercial products separated (VS) or combined (VC). Both vaccinated groups showed significant differences for most parameters measured regarding PCV-2 (serology, percentage of infected animals and viral load in tissues) and Mhyo (serology and gross lesions) when compared to NV groups. VS and VC offered similar results, being only significantly different the PCV-2 antibody values at different time points (higher in the VS group) of the study, although not at the termination day (21 days post-PCV-2 inoculation).
Conclusion
The present study expands the knowledge on the possibility of using two separate Mhyo and PCV-2 commercial vaccines as a RTM product, which offered equivalent virological, immunological and pathological outcomes as compared to these vaccines when used by separate.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
11
Publisher
BMC
Is part of
Porcine Health Management
Citation
Sibila, M., G. Guevara, R. Cuadrado, P. Pleguezuelos, D. Pérez, A. Pérez de Rozas, and E. Huerta et al. 2020. "Comparison Of Mycoplasma Hyopneumoniae And Porcine Circovirus 2 Commercial Vaccines Efficacy When Applied Separate Or Combined Under Experimental Conditions". Porcine Health Management 6 (1). Springer Science and Business Media LLC. doi:10.1186/s40813-020-00148-0.
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2831]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/