Single-step genome-wide association study for social genetic effects and direct genetic effects on growth in Landrace pigs
Autor/a
Hong, Joon-Ki
Lee, Jae-Bong
Kim, Si-Dong
Cho, Eun-Seok
Kim, Young-Sin
Cho, Kyu-Ho
Lee, Deuk-Hwan
Park, Hee-Bok
Fecha de publicación
2020-09-11ISSN
2045-2322
Resumen
In livestock social interactions, social genetic effects (SGE) represent associations between phenotype of one individual and genotype of another. Such associations occur when the trait of interest is affected by transmissible phenotypes of social partners. The aim of this study was to estimate SGE and direct genetic effects (DGE, genetic effects of an individual on its own phenotype) on average daily gain (ADG) in Landrace pigs, and to conduct single-step genome-wide association study using SGE and DGE as dependent variables to identify quantitative trait loci (QTLs) and their positional candidate genes. A total of 1,041 Landrace pigs were genotyped using the Porcine SNP 60K BeadChip. Estimates of the two effects were obtained using an extended animal model. The SGE contributed 16% of the total heritable variation of ADG. The total heritability estimated by the extended animal model including both SGE and DGE was 0.52. The single-step genome-wide association study identified a total of 23 QTL windows for the SGE on ADG distributed across three chromosomes (i.e., SSC1, SSC2, and SSC6). Positional candidate genes within these QTL regions included PRDM13, MAP3K7, CNR1, HTR1E, IL4, IL5, IL13, KIF3A, EFHD2, SLC38A7, mTOR, CNOT1, PLCB2, GABRR1, and GABRR2, which have biological roles in neuropsychiatric processes. The results of biological pathway and gene network analyses also support the association of the neuropsychiatric processes with SGE on ADG in pigs. Additionally, a total of 11 QTL windows for DGE on ADG in SSC2, 3, 6, 9, 10, 12, 14, 16, and 17 were detected with positional candidate genes such as ARL15. We found a putative pleotropic QTL for both SGE and DGE on ADG on SSC6. Our results in this study provide important insights that can help facilitate a better understanding of the molecular basis of SGE for socially affected traits.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
636 - Explotación y cría de animales. Cría del ganado y de animales domésticos
Páginas
11
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Hong, Joon-Ki, Jae-Bong Lee, Yuliaxis Ramayo-Caldas, Si-Dong Kim, Eun-Seok Cho, Young-Sin Kim, Kyu-Ho Cho, Deuk-Hwan Lee, and Hee-Bok Park. 2020. "Single-Step Genome-Wide Association Study For Social Genetic Effects And Direct Genetic Effects On Growth In Landrace Pigs". Scientific Reports 10 (1). doi:10.1038/s41598-020-71647-x.
Program
Genètica i Millora Animal
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