Browsing ARTICLES CIENTÍFICS by Author "Te, Nigeer"
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Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein
Rodon, Jordi; Okba, Nisreen M. A.; Te, Nigeer; van Dieren, Brenda; Bosch, Berend-Jan; Bensaid, Albert; Segalés, Joaquim; Haagmans, Bart L.; Serra Gironella, Joan (Emerging Microbes and Infections, 2019-11-12) Sanitat AnimalThe ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, ... -
Co‐localization of Middle East respiratory syndrome coronavirus (MERS‐CoV) and dipeptidyl peptidase‐4 in the respiratory tract and lymphoid tissues of pigs and llamas
Te, Nigeer; Vergara‐Alert, Júlia; Lehmbecker, Annika; Pérez, Mónica; Haagmans, Bart L.; Baumgärtner, Wolfgang; Bensaid, Albert; Segalés, Joaquim (Transboundary and Emerging Diseases, 2018-12-06) Sanitat AnimalThis study investigated the co‐localization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) and its receptor dipeptidyl peptidase‐4 (DPP4) by immunohistochemistry (IHC) across respiratory ... -
Detection of MERS-CoV antigen on formalin-fixed paraffin-embedded nasal tissue of alpacas by immunohistochemistry using human monoclonal antibodies directed against different epitopes of the spike protein
Haverkamp, Ann-Kathrin; Bosch, Berend J.; Spitzbarth, Ingo; Lehmbecker, Annika; Te, Nigeer; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang (Veterinary Immunology and Immunopathology, 2019-09-09) Sanitat AnimalMiddle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one third of human patients. In recent years, several investigators developed protective ... -
Enhanced antiviral immunity and dampened inflammation in llama lymph nodes upon MERS-CoV sensing: bridging innate and adaptive cellular immune responses in camelid reservoirs
Rodon, Jordi; Te, Nigeer; Segalés, Joaquim; Serra Gironella, Joan; Bensaid, Albert (Frontiers in Immunology, 2023-06-14) Sanitat AnimalMiddle East respiratory syndrome coronavirus (MERS-CoV) infection can cause fatal pulmonary inflammatory disease in humans. Contrarily, camelids and bats are the main reservoir hosts, tolerant for ... -
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
Te, Nigeer; Rodon, Jordi; Pérez, Mónica; Segalés, Joaquim; Serra Gironella, Joan; Bensaid, Albert (Emerging Microbes and Infections, 2022-02-01) Sanitat AnimalMiddle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle East region are subdivided into two clades (A and B), all ... -
Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
Te, Nigeer; Rodon Aldrufeu, Jordi; Creve, Rhea; Pérez, Mónica; Segalés, Joaquim; Serra Gironella, Joan; Bensaid, Albert (Veterinary Research, 2022-09-02) Sanitat AnimalMiddle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to public health. Here, we established an ex vivo alpaca tracheal explant (ATE) model using an air-liquid interface culture ... -
Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain
Rodon, Jordi; Mykytyn, Anna Z.; Te, Nigeer; Okba, Nisreen M.A.; Lamers, Mart M.; Pailler-García, Lola; Cantero, Guillermo; Albulescu, Irina; Bosch, Berend-Jan; Peiris, Malik; Bensaid, Albert; Serra Gironella, Joan; Haagmans, Bart L.; Segalés, Joaquim (Emerging Infectious Diseases, 2023-02-07) Sanitat AnimalMiddle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended ... -
Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
Rodon, Jordi; Sachse, Martin; Te, Nigeer; Segalés, Joaquim; Bensaid, Albert; Risco, Cristina; Serra Gironella, Joan (Microbes and Infection, 2024-03) Sanitat AnimalSevere Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high ... -
Middle East respiratory syndrome coronavirus infection in camelids
Te, Nigeer; Ciurkiewicz, Malgorzata; van den Brand, Judith M. A.; Rodon, Jordi; Haverkamp, Ann-Kathrin; Serra Gironella, Joan; Bensaid, Albert; Haagmans, Bart L.; Baumgartner, Wolfgang; Segalés, Joaquim (Veterinary Pathology, 2022-01-08) Sanitat AnimalMiddle East respiratory syndrome coronavirus (MERS-CoV) is the cause of a severe respiratory disease with a high case fatality rate in humans. Since its emergence in mid-2012, 2578 laboratory-confirmed ... -
Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies
Serra Gironella, Joan; Rodon, Jordi; Carrillo, Jorge; Te, Nigeer; Izquierdo-Useros, Nuria; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Guallar, Víctor; Valencia, Alfonso; Cantero, Guillermo; Blanco, Julià; Clotet, Buenaventura; Bensaid, Albert; Segalés, Joaquim (Transboundary and Emerging Diseases, 2020-10-02) Sanitat AnimalConventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. ... -
Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster
Brustolin, Marco; Rodon, Jordi; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Cantero, Guillermo; Pérez, Mónica; Te, Nigeer; Noguera-Julián, Marc; Guallar, Víctor; Valencia, Alfonso; Roca, Núria; Izquierdo-Useros, Nuria; Blanco, Julià; Clotet, Bonaventura; Bensaid, Albert; Carrillo, Jorge; Serra Gironella, Joan; Segalés, Joaquim (Emerging Microbes and Infections, 2021-04-29) Sanitat AnimalReinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question ... -
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection
Te, Nigeer; Rodon, Jordi; Ballester, Maria; Pérez, Mónica; Pailler García, Lola; Segalés, Joaquim; Serra Gironella, Joan; Bensaid, Albert (PLoS Pathogens, 2021-05-24) Sanitat Animal; Genètica i Millora AnimalWhile MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate ...